Cardinals vs 49ers Odds & Live Scores - September 21, 2025

Cardinals at 49ers

8:25 pm • FOX

Arizona Cardinals

3-6

15 - 16

San Francisco 49ers

7-1

MatchupOpenSpreadTotalMoneyline
Cardinals 3-6	+1.5-110	o44.5-110	+105
49ers 7-1	-1.5-110	u44.5-110	-125

Sunday 8:25 p.m.

September 21, 2025

Levi's StadiumSanta Clara

ARI +1.5-110

SF -1.5-107

0.27u

K.Murray Anytime TD Scorer Yes+380

0.25u

Via @GDAWG5000

C.McCaffrey o36.5 Rec Yds-115

Over 43-115

0.58u

ARI +2.5-105

C.McCaffrey Anytime TD Scorer Yes-177

0.89u

Projection: -233. For more, check out the Fantasy Life player projections.

Over 44.5-108

1.08u

Projection: 46.3. For more, check out the Fantasy Life game model.

SF -120

SF +100

0.5u

ARI +130

$1.00

SF +100

SF +1-110

0.91u

SF -2.5-115

1.15u

SF +100

M.Harrison o47.5 Rec Yds-115

1.15u

MGM

K.Murray Anytime TD Scorer Yes+380

Let’s Ride!

Under 43.5-110

0.91u

SF -120

0.83u

Mac Jones ML

Under 42 (Live)+750

22.5u

ARI +2.5-115

0.87u

SF +230 (Live)

5.75u

Final drive 3 to win. Be a hero Mac.

J.Tonges o2.5 Recs+105

SF -120

0.83u

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NFL Public Betting

49ers are 5-0 in their last 5 games.
49ers are 3-2 in their last 5 games against the spread
49ers are 1-1 in their road games against the spread
The totals have gone OVER in 2 of 49ers' last 5 games
The totals have gone OVER in 3 of 49ers' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	5-3	3-2	1-1	3-3	2-0
Cardinals	4-5	0-3	4-2	0-1	4-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	4-4	3-2	1-1	3-3	1-1
Cardinals	5-4	2-1	3-3	1-0	4-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	7-1	N/A	N/A	5-1	2-0
Cardinals	3-6	N/A	N/A	0-1	3-5

date	opponent	score	spread	over/under	moneyline
Sep 14th	@NO	W 26-21	-3 W	O 40.5	SF -160
Sep 7th	@SEA	W 17-13	-2.5 W	U 43.5	SF -132
Aug 24th	LAC	W 30-23	+2.5 W	O 35.5	SF +125
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240

Kendrick Bourne
WR
Bourne is out with ankle
Out
James Conner
RB
Conner is out with foot
Out
Gardner Minshew
QB
Minshew is out with elbow
Out
Hunter Long
TE
Long is out with knee
Out
Michael Wilson
WR
Wilson is out with neck
Out
Jalen Brooks
WR
Brooks is out with unknown
Out
Jeremiyah Love
RB
Love is out with ankle
Out

Mike Evans
WR
Evans is doubtful with achilles
Doubtful
Christian Kirk
WR
Kirk is out with knee
Out
Deebo Samuel
WR
Samuel is questionable with hamstring
Questionable
Jake Tonges
TE
Tonges is out with knee
Out
De'Zhaun Stribling
WR
Stribling is out with ankle
Out

See more NFL Injuries

Cardinals

Total

49ers

260

Total Yards

355

Total Plays

4.1

Yards Per Play

5.7

Cardinals

Passing

49ers

159

YDS

284

22/35

Comps/Atts

27/41

4.278

YPA

6.714

1/0

TDs/INTs

1/1

1/5

Sacks/Yards

1/2

Cardinals

Rushing

49ers

106

Rush Yards

Attempts

3.786

YPC

3.65

TDs

Cardinals

Turnovers

49ers

Fumbles Lost

Interceptions

Cardinals

Efficiency

49ers

1/3 33.33%

Redzone

1/4 25%

5/15 0%

3rd Down

2/10 0%

2/2 0%

4th Down

1/2 0%

Cardinals

First Downs

49ers

Total

Pass

Rush

Penalty

Cardinals

Misc

49ers

5/30

Penalties/Yards

5/69

34:39

Possession

25:21

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MatchupOverUnder
Cardinals 3-6	N/A	N/A
49ers 7-1	N/A	N/A

Cardinals vs. 49ers Odds & Betting Predictions - September 21, 2025

Cardinals at 49ers

Arizona Cardinals

San Francisco 49ers

Cardinals at 49ers Odds

Spread, Total, Moneyline

Cardinals vs. 49ers Previews & Analysis

Cardinals vs. 49ers: Over/Under Pick for Today's Game

Anytime Touchdown Picks for Every NFL Game

A 50-1 TD Pick Leads Best Late-Slate Bets

14-1, 9-1 Sleepers Lead Top ATD Edges

Cardinals vs. 49ers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

Cardinals vs. 49ers Public Betting Percentages

Cardinals

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Cardinals vs. 49ers Injury Updates

Cardinals Injuries

49ers Injuries

Cardinals vs. 49ers Odds Comparison

Cardinals at 49ers Team Totals