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Cardinals vs. 49ers Odds & Betting Predictions - September 21, 2025

Cardinals at 49ers

8:25 pm • FOX
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Arizona Cardinals

0-0
@

San Francisco 49ers

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Cardinals at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
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49ers
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location pinSunday 8:25 p.m.
September 21, 2025
Levi's StadiumSanta Clara

Cardinals vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Cardinals vs. 49ers Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Cardinals		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 24thLACW 30-23+2.5 WO 35.5SF +125
Aug 16th@LVW 22-19+4.5 WO 40.5SF +180
Aug 10thDENL 9-30+6.5 LO 38.5DEN +240
Jan 5th@ARIL 24-47+5.5 LO 43.5ARI +195
Dec 31stDETL 34-40+4 LO 50.5DET +182

49ers vs. Cardinals Injury Updates

49ers Injuries

  • Demarcus Robinson
    WR

    Robinson is out with suspension

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Cardinals Injuries

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    Depth Charts
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    Starter2ND3RD4TH
    QBBrock PurdyMac JonesKurtis Rourke
    RBChristian McCaffreyIsaac GuerendoJordan James
    WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
    TEGeorge KittleLuke FarrellJake TongesBrayden Willis
    LTTrent WilliamsSpencer Burford
    LGBen BartchNick Zakelj
    CJake BrendelMatt HennessyDrake Nugent
    RGDominick PuniConnor ColbyDrew Moss
    RTColton McKivitzAusten Pleasants
    LDENick BosaYetur Gross-MatosRobert Beal
    RDEMykel WilliamsBryce HuffSam OkuayinonuTrevis Gipson
    WLBDee WintersNick MartinJalen Graham
    MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
    LCBRenardo GreenJakob Robinson
    SSJi'Ayir BrownMalik MustaphaDerrick Canteen
    FSJason PinnockMarques SigleSiran Neal
    RCBDeommodore LenoirDarrell Luter
    PThomas Morstead
    PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
    KRIsaac GuerendoJunior Bergen
    LSJon Weeks
    KJake Moody
    FBKyle Juszczyk
    RWRRicky PearsallJordan WatkinsMalik Turner
    LWRBrandon AiyukRobbie ChosenMalik Turner
    NTJordan ElliottC.J. WestKalia Davis
    DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
    NBUpton StoutChase Lucas

    Cardinals vs. 49ers Odds Comparison

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    Cardinals at 49ers Team Totals

    MatchupOverUnder
    Cardinals
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    N/A
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    49ers
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    N/A
    N/A