Cardinals vs 49ers Odds & Live Scores - September 21, 2025

Cardinals at 49ers

8:25 pm • FOX

Arizona Cardinals

0-1

15 - 16

San Francisco 49ers

0-0

MatchupOpenSpreadTotalMoneyline
Cardinals 0-1	+1.5-110	o44.5-110	+105
49ers 0-0	-1.5-110	u44.5-110	-125

Sunday 8:25 p.m.

September 21, 2025

Levi's StadiumSanta Clara

Under 42 (Live)+750

22.5u

SF +230 (Live)

5.75u

Final drive 3 to win. Be a hero Mac.

SF -120

0.83u

Mac Jones ML

SF -2.5-115

1.15u

ARI +1.5-110

J.Tonges o2.5 Recs+105

Over 44.5-108

1.08u

Projection: 46.3. For more, check out the Fantasy Life game model.

ARI +2.5-110

Under 45.5-112

0.98u

C.McCaffrey Anytime TD Scorer Yes-177

0.89u

Projection: -233. For more, check out the Fantasy Life player projections.

ARI +2.5-115

1.5u

ARI +2.5-115

0.87u

SF -1.5-107

0.27u

M.Harrison o47.5 Rec Yds-115

1.15u

MGM

K.Murray Anytime TD Scorer Yes+380

0.25u

Via @GDAWG5000

K.Murray Anytime TD Scorer Yes+380

Let’s Ride!

ARI +2.5-105

SF -120

0.83u

SF -120

ARI +130

$1.00

SF +100

0.5u

SF +100

SF +1-110

0.91u

Under 43.5-110

0.91u

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NFL Public Betting

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	N/A	N/A	N/A	N/A	N/A
Cardinals	N/A	N/A	N/A	N/A	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	N/A	N/A	N/A	N/A	N/A
Cardinals	N/A	N/A	N/A	N/A	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	N/A	N/A	N/A	N/A	N/A
Cardinals	N/A	N/A	N/A	N/A	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@NO	W 26-21	-3 W	O 40.5	SF -160
Sep 7th	@SEA	W 17-13	-2.5 W	U 43.5	SF -132
Aug 24th	LAC	W 30-23	+2.5 W	O 35.5	SF +125
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240

Cardinals

Total

49ers

260

Total Yards

355

Total Plays

4.1

Yards Per Play

5.7

Cardinals

Passing

49ers

159

YDS

284

22/35

Comps/Atts

27/41

4.278

YPA

6.714

1/0

TDs/INTs

1/1

1/5

Sacks/Yards

1/2

Cardinals

Rushing

49ers

106

Rush Yards

Attempts

3.786

YPC

3.65

TDs

Cardinals

Turnovers

49ers

Fumbles Lost

Interceptions

Cardinals

Efficiency

49ers

1/3 33.33%

Redzone

1/4 25%

5/15 0%

3rd Down

2/10 0%

2/2 0%

4th Down

1/2 0%

Cardinals

First Downs

49ers

Total

Pass

Rush

Penalty

Cardinals

Misc

49ers

5/30

Penalties/Yards

5/69

34:39

Possession

25:21

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MatchupOverUnder
Cardinals 0-1	N/A	N/A
49ers 0-0	N/A	N/A

Cardinals vs. 49ers Odds & Betting Predictions - September 21, 2025

Cardinals at 49ers

Arizona Cardinals

San Francisco 49ers

Cardinals at 49ers Odds

Spread, Total, Moneyline

Cardinals vs. 49ers Previews & Analysis

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A 50-1 TD Pick Leads Best Late-Slate Bets

14-1, 9-1 Sleepers Lead Top ATD Edges

Cardinals vs. 49ers Props

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Prop Odds Comparison

Line Movement Tracker

Cardinals vs. 49ers Public Betting Percentages

Cardinals

Public

49ers

Bets%

Money%

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Cardinals vs. 49ers Odds Comparison

Cardinals at 49ers Team Totals