49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025
49ers at Seahawks
8:05 pm • FOX49ers at Seahawks Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 6-1 | -2.5-112 | o43.5-110 | -132 | |
 Seahawks 3-3 | +2.5-108 | u43.5-110 | +112 | |
Lumen FieldSeattle, WA
49ers vs. Seahawks Expert Picks
Vegas Refund
Last 30d: 32-43-2 (-15.7u)
SEA +2-110
1.1u
Sean Zerillo
Last 30d: 142-140-7 (+2.0u)
SEA +111
0.25u
Exchange
Tyler Shoemaker
Last 30d: 29-32-0 (-0.1u)
SEA +2.5-110
5.5u
Kenny Ducey
Last 30d: 4-2-0 (+2.0u)
SEA +1.5-110
1.1u
Matthew Freedman
Last 30d: 0-0-0 (+0.0u)
Over 43.5-104
1.04u
Projection: 45.6. For more, check out the Fantasy Life game model.
Anthony Dabbundo
Last 30d: 47-66-0 (-20.8u)
SEA +2.5-110
1.1u
#TheRinger107
Under 20 (2H)-105
0.5u
Wanted 20.5 so I’ll play this smaller
Doug Ziefel
Last 30d: 427-417-9 (+35.7u)
B.Purdy u21.5 Pass Comp-115
0.58u
C.Kupp o3.5 Recs-107
0.54u
Jeremiah Rose
Last 30d: 58-65-3 (-2.0u)
C.McCaffrey Anytime TD Scorer Yes-120
0.1u
Promo Boost
Ryan Minion
Last 30d: 249-234-3 (+27.2u)
C.Kupp o3.5 Recs-135
$1.35
Grant Neiffer
Last 30d: 24-83-4 (+0.4u)
G.Kittle Anytime TD Scorer Yes+175
0.88u
MJC
Last 30d: 9-12-0 (+6.5u)
B.Purdy 2+ TDs Yes+10000
0.05u
B.Purdy Anytime TD Scorer Yes+650
0.15u
B.Purdy o3.5 Rush Att-115
1u
Brandon Anderson
Last 30d: 37-121-1 (-12.1u)
K.Walker o59.5 Rush Yds-115
0.75u
There's also one key matchup that's very worrying for San Francisco: Seattle's run game.
Klint Kubiak is the new play caller in Seattle, and if preseason is any indication, his presence could transform this Seahawks rushing attack. A young offensive line that was widely panned as consensus bottom-three in the league suddenly looked outstanding, and Seattle was ripping off big runs left and right.
San Francisco's pass defense was good last season, but the 49ers ranked bottom 10 by DVOA against the run and entire the season with a gaping hole at defensive tackle. The 49ers allowed the 5th most fantasy points to opposing RBs last season, letting 10 RBs rush for 70+ yards and giving up a league-high 18 rushing TDs to opposing RBs.
Kenneth Walker looks healthy and should get plenty of touches in Kubiak's system. He had a touchdown in both 49ers games last fall.
Let's back Walker to go over 59.5 yards, and as a slight escalator, we'll place a portion of our bet on Walker going over his rushing line and also finding the endzone at +323 (FanDuel).
Chris Gimino
Last 30d: 6-7-0 (-0.6u)
B.Purdy u32.5 Pass Att-115
1u
Austin Pendergrass
Last 30d: 74-50-0 (+10.7u)
R.Pearsall o3.5 Recs-125
0.4u
Brandon Kravitz
Last 30d: 59-61-2 (+7.1u)
SEA +1.5-105
1.05u
Gilles Gallant
Last 30d: 26-67-1 (-1.7u)
G.Kittle Anytime TD Scorer Yes+190
1.9u
Nick Giffen
Last 30d: 48-149-0 (-1.0u)
Over 43-110
0.55u
Action Playbook LIVE
Z.Charbonnet Last TD Scorer Yes+1700
0.1u
Z.Charbonnet Anytime TD Scorer Yes+390
1.95u
Topper
Last 30d: 160-148-8 (+5.3u)
SEA +1.5-105
1.05u
Early season divisional underdogs
Overall: 130-66-6,66% (ROI:27%)
Under 43.5-110
0.91u
S.Darnold o1.5 Pass TDs+160
0.5u
Action Pod NFL Picks
Last 30d: 46-128-1 (-12.2u)
K.Walker o59.5 Rush Yds-115
1u
@wheatonbrando https://myaction.app/TqfB5ck7pWb
Mjaybrod
Last 30d: 57-78-1 (-23.1u)
Under 43.5-110
0.91u
Nasty one
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey Anytime TD Scorer Yes-125
1u
💰🦡 Jake
Last 30d: 101-111-1 (+21.9u)
SF -0.5 (1H)-110
1.1u
Sir Lockselot
Last 30d: 18-39-0 (+4.2u)
C.McCaffrey Anytime TD Scorer Yes-135
3u
📚Player Profit
🔑 C.McCaffrey ATTD -135 (Player Profit) 3u
If you saw money on the ground, would you pick it up? This is the best odds you are gonna get all year on CMC. Take the free money and run.
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JC Cornell
Last 30d: 0-0-0 (+0.0u)
Z.Charbonnet o1 Longest Rush (Live)-110
1u
C.McCaffrey Anytime TD Scorer Yes (Live)+130
0.77u
R.Pearsall o69.5 Rec Yds (Live)-117
2.56u
J.Smith-Njigba o80.5 Rec Yds (Live)-115
2.61u
Z.Charbonnet o51.5 Rush Yds (Live)-114
1.14u
49ers vs. Seahawks Previews & Analysis
49ers vs. Seahawks Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Seahawks Public Betting Percentages
Betting Trends
- Seahawks are 3-2 in their last 5 games.
- Seahawks are 1-3 in their last 5 games against the spread
- Seahawks are 1-2 in their road games against the spread
- The totals have gone OVER in 2 of Seahawks' last 5 games
- The totals have gone OVER in 2 of Seahawks' 3 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Seahawks Injury Updates
49ers Injuries
- Mike EvansWR
Evans is out with achilles
Out
- Demarcus RobinsonWR
Robinson is out with ankle
Out
- Deebo SamuelWR
Samuel is out with hamstring
Out
- Jake TongesTE
Tonges is out with knee
Out
- De'Zhaun StriblingWR
Stribling is out with ankle
Out
Seahawks Injuries
- Zach CharbonnetRB
Charbonnet is out with knee
Out
- Elijah ArroyoTE
Arroyo is out with shoulder
Out
- Jadarian PriceRB
Price is out with chest
Out
Team Stats
49ers vs. Seahawks Odds Comparison
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49ers at Seahawks Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 6-1 | N/A | N/A |
Seahawks 3-3 | N/A | N/A |