49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025

49ers at Seahawks

8:05 pm • FOX

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San Francisco 49ers

1-1

Seattle Seahawks

1-0-1

MatchupOpenSpreadTotalMoneyline
49ers 1-1	-1.5	-2.5-110	o45.5-105	-138
Seahawks 1-0-1	u45.5	+2.5-110	u45.5-115	+118

Sunday 8:05 p.m.

September 07, 2025

Lumen FieldSeattle

SEA +1.5-105

1.05u

Early season divisional underdogs Overall: 130-66-6,66% (ROI:27%)

NFL Schedule Release Betting Primer: Notes, Stats and Trends for 2025 Season
Evan Abrams•
May 15, 2025 UTC

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NFL Public Betting

Seahawks are 3-2 in their last 5 games.
Seahawks are 1-3 in their last 5 games against the spread
Seahawks are 4-3 in their road games against the spread
The totals have gone OVER in 3 of Seahawks' last 5 games
The totals have gone OVER in 4 of Seahawks' 9 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Seahawks	6-10-1	2-7	4-3-1	1-4-1	5-6
49ers	5-12	4-5	1-7	5-8	0-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Seahawks	9-8	4-5	5-3	4-2	5-6
49ers	10-7	5-4	5-3	7-6	3-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Seahawks	10-7	N/A	N/A	5-1	5-6
49ers	6-11	N/A	N/A	6-7	0-4

date	opponent	score	spread	over/under	moneyline
Aug 16th	KC	W 33-16	-5 W	O 38	SEA -220
Aug 8th	LV	W 23-23	+5.5 W	O 36.5	LV +200
Jan 5th	@LA	W 30-25	-7.5 L	O 38.5	SEA -350
Dec 27th	@CHI	W 6-3	-4.5 L	U 42.5	SEA -225
Dec 22nd	MIN	L 24-27	+2.5 L	O 43	MIN +124

Trevis Gipson
LB
Gipson is out with ankle
Out

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passing yards
-
4320
pyds
passing touchdowns
-
21
ptd
rushing yards
Kenneth Walker
573
ryds
rushing touchdowns
Zach Charbonnet
8
rtd

	Starter	2ND	3RD	4TH
QB	Geno Smith	Sam Howell
RB	Kenneth Walker	Zach Charbonnet	Kenny McIntosh	George Holani
WR	Jaxon Smith-Njigba
TE	Noah Fant	Pharaoh Brown	AJ Barner	Brady Russell
LT	Charles Cross	Stone Forsythe
LG	Laken Tomlinson
C	Olu Oluwatimi	Jalen Sundell
RG	Anthony Bradford	Christian Haynes	Sataoa Laumea
RT	Abraham Lucas	George Fant	Michael Jerrell
WLB	Tyrice Knight
MLB	Drake Thomas	Patrick O'Connell
SLB	Uchenna Nwosu	Derick Hall	Jamie Sheriff
LCB	Tre Brown
SS	Rayshawn Jenkins	K'Von Wallace
FS	Julian Love	Coby Bryant	Ty Okada
RCB	Riq Woolen	Nehemiah Pritchett
P	Michael Dickson
H	Michael Dickson
LS	Chris Stoll
DE	Jarran Reed	Byron Murphy
RUSH	Dre'Mont Jones	Boye Mafe
K	Jason Myers
LWR	DK Metcalf	Jake Bobo	Cody White
RWR	Tyler Lockett	Dareke Young
NT	Johnathan Hankins	Cameron Young
NB	Devon Witherspoon	Artie Burns
DT	Leonard Williams	Mike Morris

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MatchupOverUnder
49ers 1-1	N/A	N/A
Seahawks 1-0-1	N/A	N/A

49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025

49ers at Seahawks

San Francisco 49ers

Seattle Seahawks

49ers at Seahawks Odds

Spread, Total, Moneyline

49ers vs. Seahawks Previews & Analysis

NFL Schedule Release Betting Primer: Notes, Stats and Trends for 2025 Season

49ers vs. Seahawks Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

49ers vs. Seahawks Public Betting Percentages

49ers

Public

Seahawks

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Seahawks vs. 49ers Injury Updates

Seahawks Injuries

49ers Injuries

49ers vs. Seahawks Odds Comparison

49ers at Seahawks Team Totals