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49ers vs. Saints Odds & Betting Predictions - September 14, 2025

49ers at Saints

5:00 pm • FOX
Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

6-11
@

New Orleans Saints

5-12

49ers at Saints Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
6-11
N/A
N/A
-325
Saints
5-12
N/A
N/A
+260
location pinSunday 5:00 p.m.
September 14, 2025
Caesars SuperdomeNew Orleans

49ers vs. Saints Props

Prop Projections

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49ers vs. Saints Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Saints

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Saints are 3-2 in their last 5 games.
  • Saints are 4-1 in their last 5 games against the spread
  • Saints are 3-5 in their road games against the spread
  • The totals have gone OVER in 3 of Saints' last 5 games
  • The totals have gone OVER in 4 of Saints' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Saints		7-104-53-51-36-7
49ers		5-124-51-75-80-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Saints		8-94-54-42-26-7
49ers		10-75-45-37-63-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Saints		5-12N/AN/A2-23-10
49ers		6-11N/AN/A6-70-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 5th@TBL 19-27+14.5 WO 44.5TB +722
Dec 29thLVL 10-25+2 LU 37.5LV +105
Dec 24th@GBL 0-34+14.5 LU 43.5GB +683
Dec 15thWASL 19-20+7.5 WU 44.5WAS +290
Dec 8th@NYGW 14-11-4.5 LU 40.5NO -225

Saints vs. 49ers Injury Updates

Saints Injuries

  • Alvin Kamara
    RB

    Kamara is doubtful with groin

    Doubtful

  • Taysom Hill
    TE

    Hill is out with knee

    Out

  • Nathan Shepherd
    DT

    Shepherd is questionable with eye

    Questionable

  • Isaac Yiadom
    CB

    Yiadom is questionable with pelvis

    Questionable

  • J.T. Gray
    DB

    Gray is questionable with back

    Questionable

  • Erik McCoy
    OL

    McCoy is out with elbow

    Out

  • Cam Akers
    RB

    Akers is questionable with illness

    Questionable

  • Pete Werner
    LB

    Werner is out with concussion

    Out

  • Chris Olave
    WR

    Olave is out with concussion

    Out

  • D'Marco Jackson
    LB

    Jackson is out with ankle

    Out

  • John Ridgeway
    DT

    Ridgeway is questionable with oblique

    Questionable

  • Nephi Sewell
    LB

    Sewell is questionable with knee

    Questionable

  • Rashid Shaheed
    WR

    Shaheed is out with knee

    Out

  • Kendre Miller
    RB

    Miller is doubtful with concussion

    Doubtful

  • Nick Saldiveri
    OL

    Saldiveri is out with knee

    Out

  • Bub Means
    WR

    Means is out with ankle

    Out

  • Rico Payton
    CB

    Payton is questionable with back

    Questionable

49ers Injuries

  • Trent Williams
    T

    Williams is out with ankle

    Out

  • Christian McCaffrey
    RB

    McCaffrey is out with knee

    Out

  • George Kittle
    TE

    Kittle is questionable with ankle

    Questionable

  • George Odum
    S

    Odum is out with knee

    Out

  • Greg Joseph
    K

    Joseph is out with abdomen

    Out

  • Kevin Givens
    DE

    Givens is questionable with groin

    Questionable

  • Andre Dillard
    OL

    Dillard is questionable with concussion

    Questionable

  • Brandon Aiyuk
    WR

    Aiyuk is out with leg

    Out

  • Colton McKivitz
    OL

    McKivitz is questionable with knee

    Questionable

  • Ben Bartch
    OL

    Bartch is out with ankle

    Out

  • Deommodore Lenoir
    DB

    Lenoir is out with shoulder

    Out

  • Spencer Burford
    OL

    Burford is out with calf

    Out

  • Brock Purdy
    QB

    Purdy is out with elbow

    Out

  • Ji'Ayir Brown
    S

    Brown is questionable with ankle

    Questionable

  • Robert Beal
    DE

    Beal is out with ankle

    Out

  • Darrell Luter
    CB

    Luter is doubtful with pelvis

    Doubtful

  • Renardo Green
    CB

    Green is questionable with neck

    Questionable

See more NFL Injuries Right Arrow
Depth Charts
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Starter2ND3RD4TH
QBDerek CarrJake HaenerSpencer Rattler
RBAlvin KamaraJamaal WilliamsKendre MillerJordan Mims
WRRashid ShaheedBub MeansMason Tipton
TEJuwan JohnsonFoster MoreauTaysom HillMichael Jacobson
LTTaliese FuagaLandon Young
LGLucas PatrickNick Saldiveri
CErik McCoyShane Lemieux
RGCesar RuizKyle Hergel
RTTrevor PenningOlisaemeka UdohJosiah Ezirim
LDECameron JordanPayton TurnerTrajan Jeffcoat
LDTKhalen SaundersKhristian Boyd
RDTNathan ShepherdBryan Bresee
RDECarl GrandersonChase YoungIsaiah Foskey
WLBPete WernerIsaiah Stalbird
MLBDemario DavisD'Marco Jackson
SLBWillie GayJaylan FordAnfernee Orji
LCBPaulson AdeboShemar Jean-CharlesRejzohn Wright
SSJordan HowdenJ.T. GrayMillard Bradford
FSTyrann MathieuWill Harris
RCBKool-Aid McKinstryRico Payton
PMatthew Hayball
HMatthew Hayball
PRRashid ShaheedMason Tipton
KRRashid ShaheedJamaal Williams
LSZach Wood
KBlake GrupeCharlie Smyth
RWRChris OlaveCedrick Wilson
NBAlontae TaylorUgo Amadi
FBAdam Prentice
LWRKevin Austin

49ers vs. Saints Odds Comparison

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49ers at Saints Team Totals

MatchupOverUnder
49ers
6-11
N/A
N/A
Saints
5-12
N/A
N/A