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49ers vs. Saints Odds & Betting Predictions - September 14, 2025

49ers at Saints

5:00 pm • FOX
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San Francisco 49ers

0-0
@

New Orleans Saints

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49ers at Saints Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
0-0
-7
-7-105
o44.5-110
-340
Saints
0-0
u44.5
+7-115
u44.5-110
+270
location pinSunday 5:00 p.m.
September 14, 2025
Caesars SuperdomeNew Orleans

49ers vs. Saints Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Saints Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Saints

53%

Bets%

47%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Saints		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Saints		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Saints		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 23rdDENL 19-28+2.5 LO 38.5DEN +120
Aug 17thJACW 17-17+2.5 WU 40.5JAC +112
Aug 10th@LACL 13-27+2.5 LO 39LAC +120
Jan 5th@TBL 19-27+14.5 WO 44.5TB +722
Dec 29thLVL 10-25+2 LU 37.5LV +105

Saints vs. 49ers Injury Updates

Saints Injuries

    49ers Injuries

    • Trevis Gipson
      LB

      Gipson is out with ankle

      Out

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    Depth Charts
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    Starter2ND3RD4TH
    QBSpencer RattlerTyler ShoughJake Haener
    RBAlvin KamaraKendre MillerVelus JonesDevin Neal
    WRDevaughn VeleCedrick Wilson
    TEJuwan JohnsonFoster MoreauTaysom HillTreyton WelchJack StollMoliki Matavao
    LTKelvin BanksLandon YoungBarry Wesley
    LGTrevor PenningDillon RadunzEaston Kilty
    CErik McCoyLuke Fortner
    RGCesar RuizTorricelli Simpkins
    RTTaliese Fuaga
    RDENathan ShepherdJonathan BullardJonah Williams
    WLBPete WernerJaylan FordNephi Sewell
    MLBDemario DavisDanny StutsmanNephi Sewell
    LCBIsaac YiadomQuincy RileyDalys Beanum
    SSJustin ReidJordan HowdenTerrell Burgess
    FSJulian BlackmonJonas SankerJ.T. GrayElliott Davison
    RCBKool-Aid McKinstryRejzohn Wright
    PKai Kroeger
    HKai Kroeger
    PRRashid ShaheedCedrick WilsonJayden Price
    KRRashid ShaheedVelus JonesKendre MillerJayden Price
    LSZach Wood
    DTBryan BreseeVernon Broughton
    LWRChris OlaveMason TiptonKevin Austin
    LOLBChase YoungCameron Jordan
    ROLBCarl GrandersonChris RumphFadil Diggs
    NTDavon GodchauxKhristian BoydJohn Ridgeway
    NBAlontae TaylorUgo AmadiJayden Price
    KBlake GrupeCharlie Smyth
    RWRRashid ShaheedBrandin Cooks

    49ers vs. Saints Odds Comparison

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    49ers at Saints Team Totals

    MatchupOverUnder
    49ers
    0-0
    N/A
    N/A
    Saints
    0-0
    N/A
    N/A