Chargers vs. Bills Odds & Betting Predictions - September 27, 2026
Chargers at Bills
5:00 pm • FOXChargers at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Chargers 0-6 | +3 | +7-115 | o50.5-106 | +272 |
 Bills 5-1 | u48.5 | -7.5-102 | u50.5-111 | -350 |
Highmark StadiumOrchard Park
Chargers vs. Bills Expert Picks
Vegas Refund
Last 30d: 33-43-2 (-14.9u)
LAC +7.5-116
1.16u
Stuck 🚨
Last 30d: 77-79-2 (+2.2u)
LAC +7-120
0.3u
*supposed to be 7.5. Need back end to update
Mike McNamara
Last 30d: 77-75-2 (-2.1u)
LAC +7.5-120
0.4u
Matt Moore
Last 30d: 28-41-2 (-4.8u)
LAC +7-105
0.55u
Tyler Shoemaker
Last 30d: 58-81-1 (-20.9u)
LAC +7.5-113
1.13u
Sean Koerner🔮
Last 30d: 53-64-0 (+1.5u)
J.Cook o10.5 Rec Yds-113
0.56u
Kind of a weird buy-low spot for Cook’s receiving market. He entered the league with more of a pass-catching profile, but that obviously isn’t his main role anymore as Buffalo’s lead back and the reigning rushing champ.
Still, the underlying usage has actually been pretty solid. Cook has caught just 4 of 7 targets, a 57% catch rate that’s roughly 22% below expected. And because I’m not just blindly trusting the math here, I went back and watched all seven targets. Could easily have 1-2 more rec so far this year and way more receiving production that game log watchers are going to see.
I prefer Over 10.5 yards to paying heavy juice on Over 1.5 receptions because Cook usually makes his catches count at 8+ yards per grab. He can clear this on one play, but I think 2-3 catches is more likely than the market suggests.
I have his median closer to 15.5 receiving yards with around a 60% chance to clear 10.5.
Anthony Dabbundo
Last 30d: 46-62-0 (-20.2u)
L.McConkey Anytime TD Scorer Yes+220
0.5u
Doug Ziefel
Last 30d: 381-422-7 (+13.9u)
L.McConkey u4.5 Recs-120
0.5u
J.Allen o1.5 Pass TDs-135
0.68u
J.Herbert Anytime TD Scorer Yes+490
0.1u
L.McConkey Anytime TD Scorer Yes+220
0.23u
P.Herbert Anytime TD Scorer Yes+1600
0.1u
J.Cook o10.5 Rec Yds-113
0.56u
Jeremiah Rose
Last 30d: 58-61-2 (-0.2u)
J.Allen Anytime TD Scorer Yes (Live)+180
0.36u
Boomer’s Book
Ryan Minion
Last 30d: 227-249-5 (-20.1u)
LAC +7-105
$1.05
LAC +300
$1.00
Q.Johnston Anytime TD Scorer Yes+250
$1.00
J.Herbert o222.5 Pass Yds-114
$1.00
Grant Neiffer
Last 30d: 24-93-4 (-2.3u)
D.Kincaid Anytime TD Scorer Yes+190
0.25u
OldSchool0909
Last 30d: 51-73-2 (-17.1u)
LAC +7-107
1u
Sandy Plashkes
Last 30d: 107-97-2 (+34.6u)
LAC +7-110
1.1u
Brandon Anderson
Last 30d: 40-115-0 (-6.8u)
O.Hampton Anytime TD Scorer Yes-115
1u
Brandon’s playground Week 3 bets
O.Hampton 2+ TDs Yes+500
0.25u
Brandon’s playground Week 3 bets
The Degenerates
Last 30d: 52-50-2 (-1.2u)
BUF o29.5-110
1.1u
Lock & Cash
Last 30d: 5-8-1 (-2.8u)
LAC +7.5-110
1u
Brandon Kravitz
Last 30d: 53-62-1 (+1.2u)
LAC +7.5-117
2.34u
RoyalsProps
Last 30d: 29-41-1 (-18.2u)
L.McConkey o54.5 Rec Yds-114
1u
Frank Ammirante
Last 30d: 103-99-0 (-10.6u)
LAC +7.5-120
1.2u
J.Herbert o226.5 Pass Yds-113
1.13u
Gilles Gallant
Last 30d: 21-63-1 (-2.6u)
J.Cook o10.5 Rec Yds-113
0.57u
Greg Matherne
Last 30d: 20-29-1 (-7.7u)
LAC +7.5-120
0.6u
Allan Lem
Last 30d: 42-33-1 (+0.3u)
P.Herbert Anytime TD Scorer Yes+1700
0.1u
Can’t resist a good narrative (he’s playing with his brother Justin Herbert in the NFL for the first time).
Let’s have some fun with this one and take a trip down Narrative Street.
Topper
Last 30d: 204-169-8 (+26.4u)
LAC +7-105
1u
Early szn Bounce Back
Overall: 336-232-10,59% (ROI:15%)
Season:4-4-0,50% (ROI:-4%)
Winless Road Teams
Overall: 212-144-5,60% (ROI:15%)
Season:4-2-0,67% (ROI:28%)
#TSA
Under 50.5-115
0.87u
High Wind Unders
Overall: 664-505-10,57% (ROI:10%)
Season:2-0-0,100% (ROI:92%)
#TSA
Action Pod NFL Picks
Last 30d: 54-113-0 (-1.8u)
O.Hampton Anytime TD Scorer Yes-115
1u
O.Hampton 2+ TDs Yes+500
0.2u
Mjaybrod
Last 30d: 57-88-1 (-30.9u)
LAC o20.5-120
1u
Adam Kaufman
Last 30d: 341-329-11 (-24.3u)
BUF -7-114
0.5u
💰🦡 Jake
Last 30d: 87-102-1 (+13.5u)
Under 25.5 (1H)-108
1.5u
Alex Hinton
Last 30d: 85-103-3 (-17.4u)
J.Cook o11.5 Rec Yds-113
1u
Scott Rickenbach
Last 30d: 83-99-4 (-25.5u)
BUF -2.5 (Live)-112
0.89u
Charlie DiSturco
Last 30d: 102-187-1 (+14.4u)
L.McConkey Anytime TD Scorer Yes+220
0.2u
J.Herbert Anytime TD Scorer Yes+500
0.2u
TAN Pod Touchdown Show
Last 30d: 26-119-6 (-10.5u)
D.Kincaid Anytime TD Scorer Yes+210
0.48u
O.Gadsden Anytime TD Scorer Yes+295
0.34u
Kev Mahserejian
Last 30d: 14-18-0 (-0.5u)
LAC +7.5-114
1u
Chargers vs. Bills Previews & Analysis
Chargers vs. Bills Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Chargers vs. Bills Public Betting Percentages
Betting Trends
- Bills are 4-1 in their last 5 games.
- Bills are 3-2 in their last 5 games against the spread
- Bills are 2-1 in their road games against the spread
- The totals have gone OVER in 4 of Bills' last 5 games
- The totals have gone OVER in 2 of Bills' 3 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Bills vs. Chargers Injury Updates
Bills Injuries
- D.J. MooreWR
Moore is questionable with shoulder
Questionable
- Joshua PalmerWR
Palmer is questionable with shoulder
Questionable
Chargers Injuries
- David NjokuTE
Njoku is out with leg
Out
- Gary JenningsWR
Gary Jennings (Concussion) is out this week.
Out
- Alec IngoldFB
Ingold is out with shoulder
Out
- Tre' HarrisWR
Harris is out with hamstring
Out
- Brenen ThompsonWR
Thompson is questionable with quad
Questionable
Team Stats
Chargers vs. Bills Odds Comparison
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Chargers at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Chargers 0-6 | N/A | N/A |
Bills 5-1 | N/A | N/A |