Eagles vs. Giants Odds & Betting Predictions - October 10, 2025

WEEK 6 LOOKAHEAD : This is one of the easier Lookahead picks of the year if you can get Eagles -7 or anything below the key number, -6.5 at BetMGM. This is a division rivalry, but is it really a rivalry? Philadelphia has won seven of the last eight meetings, and the Eagles sat their starters in the one loss in Week 18. Philly won all of the other seven games by at least six points, with an average margin of victory of 18.4 points! These games aren't even watchable. And then there's the Saquon Barkley angle. It's a homecoming and revenge game from Barkley, and he dominated in his return to New York last year, a 28-3 Eagles win. Even in a historic season, Barkley had his best YPC versus any opponent against these Giants at 10.4. This year's Giants rank dead last against the run by DVOA, so it could be a big night for Saquon. It may also be a tough night for Jaxson Dart, making his third career start on a short week of prep against this great Vic Fangio secondary, and without Malik Nabers. Thursday night favorites of seven or more points are 44-30 ATS (60%). This is Philly all the way, and there's no way we'll get this one below the starter next week. Set it and forget it — and make alternate Thursday night plans.