Browns vs. 49ers Odds, Picks & Monday Night Football Betting Predictions

Browns vs. 49ers Odds, Picks & Monday Night Football Betting Predictions article feature image

Tommy Gilligan-USA TODAY Sports. Pictured: Antonio Callaway, Baker Mayfield

  • Our staff covers every betting angle of Monday Night Football between the Cleveland Browns and San Francisco 49ers.
  • See their MNF game preview, analysis of the betting odds, favorite picks and more below.

Browns at 49ers Odds, Picks & Betting Predictions

  • Odds: 49ers -5
  • Total: 47.5
  • Time: 8:15 p.m. ET
  • TV Channel: ESPN

Odds as of 3 p.m. ET on Monday and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).

Monday Night Football Betting Guide

Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full thing here.

The 49ers have three edge defenders ranked in Pro Football Focus’ top 20 — Ronald Blair is 10th, Dee Ford is 17th and Arik Armstead is 20th — plus No. 2 overall pick Nick Bosa, who ranks 27th in pass rushing and has four QB hits on the season.

Browns left tackle Greg Robinson has been middling, ranking 24h among tackles in PFF’s grades, but the real weakness is on the right tackle, where Chris Hubbard ranks 46th among tackles and Eric Kush ranks 65th among guards.

In an opposite-coast road game against a San Francisco team fresh off a bye, the Browns’ O-line could struggle to get movement against a deep, rested 49ers’ D-line.

Read our full betting breakdown for Browns-49ers here.

Our Experts’ Browns vs. 49ers Picks

Our staff breaks down how they’re betting the spread and two player props. See their picks.

How Pros Are Betting Monday Night Football

Just about every sportsbook had this listed at 3.5 heading into Monday morning. That’s when the sharps fired. See how they’re betting the spread.

Best Prop Bets

  • Browns RB Nick Chubb’s Rushing Yards
  • 49ers WR Marquise Goodwin’s Receiving Yards
  • 49ers WR Dante Pettis’ Receptions

These are the best player prop bets for Monday night according to our tools. Here’s how to bet all three.

Monday Night Miracle Odds

Need 20 points from Odell Beckham Jr. to win your Week 5 fantasy matchup? He has an 16.60% chance of pulling out a Monday night miracle for you. Sean Koerner calculates the chances of top Browns and 49ers players getting you a win.

DFS Showdown Slate

Cash game strategy. Core GPP plays. Stacks. Chris Raybon breaks down how to play the single-game slate.

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