Week 16 NFL Odds: Spreads, Totals & Opening Lines For Every Game

Week 16 NFL Odds: Spreads, Totals & Opening Lines For Every Game article feature image
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Dylan Buell/Getty Images. Pictured: Aaron Rodgers.

With just Monday night’s Steelers-Bengals matchup remaining on the Week 15 schedule, oddsmakers have already released Week 16 opening lines.

We’ve outlined all the posted spreads and totals available as of Sunday night below.

Week 16 NFL Odds: Spreads & Totals


Odds as of Sunday night and via DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or see more offers and reviews for the best online sportsbooks.


Vikings at Saints

  • Odds: Saints -7.5
  • Over/Under: 52
  • Time: 4:30 p.m. ET on Dec. 25
  • TV Channel: FOX, NFL Network, Amazon

Buccaneers at Lions

  • Odds: Buccaneers -7.5
  • Over/Under: 53.5
  • Time: 1 p.m. ET on Dec. 26
  • TV Channel: NFL Network

49ers at Cardinals

  • Odds: Cardinals -3.5
  • Over/Under: 50
  • Time: 4:30 p.m. ET on Dec. 26
  • TV Channel: Amazon

Dolphins at Raiders

  • Odds: Dolphins -2.5
  • Over/Under: 48
  • Time: 8:15 p.m. ET on Dec. 26
  • TV Channel: NFL Network
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Panthers at Washington

  • Odds: Washington -2
  • Over/Under: TBD
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: CBS

Colts at Steelers

  • Odds: Steelers -2.5
  • Over/Under: TBD
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: CBS

Falcons at Chiefs

  • Odds: Chiefs -10.5
  • Over/Under: 53
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: FOX

Bears at Jaguars

  • Odds: Bears -7.5
  • Over/Under: 46.5
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: CBS

Bengals at Texans

  • Odds: TBD
  • Over/Under: TBD
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: FOX

Giants at Ravens

  • Odds: TBD
  • Over/Under: TBD
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: FOX

Browns at Jets

  • Odds: TBD
  • Over/Under: TBD
  • Time: 1 p.m. ET on Dec. 27
  • TV Channel: CBS

Broncos at Chargers

  • Odds: Chargers -3.5
  • Over/Under: 50
  • Time: 4:05 p.m. ET on Dec. 27
  • TV Channel: CBS

Eagles at Cowboys

  • Odds: Eagles -1.5
  • Over/Under: 49.5
  • Time: 4:25 p.m. ET on Dec. 27
  • TV Channel: FOX

Rams at Seahawks

  • Odds: Seahawks -2.5
  • Over/Under: 46.5
  • Time: 4:25 p.m. ET on Dec. 27
  • TV Channel: FOX

Titans at Packers

  • Odds: Packers -4
  • Over/Under: 55.5
  • Time: 8:20 p.m. ET on Dec. 27
  • TV Channel: NBC

Bills at Patriots

  • Odds: Bills -6.5
  • Over/Under: 45.5
  • Time: 8:15 p.m. ET on Dec. 28
  • TV Channel: ESPN