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MLB Best Bets Today: Predictions & Picks for Yankees vs Guardians, Astros vs Angels, More for Wednesday, June 10

MLB Best Bets Today: Predictions & Picks for Yankees vs Guardians, Astros vs Angels, More for Wednesday, June 10 article feature image
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Photos Courtesy of Imagn Images.

We have a full 15-game slate today, starting early with Yankees vs Guardians at 1:10 PM ET at Progressive Field on MLB.TV, and closing with Astros vs Angels at 9:38 PM ET at Angel Stadium on MLB.TV.

Our experts have analyzed the matchups and found great options for Wednesday, June 10.

Below are 4 expert MLB best bets today.


MLB Best Bets Today

The team logos in the table below represent each matchup our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
New York Yankees LogoCleveland Guardians Logo
1:10 PM
Cincinnati Reds LogoSan Diego Padres Logo
4:10 PM
Philadelphia Phillies LogoToronto Blue Jays Logo
7:07 PM
Houston Astros LogoLos Angeles Angels Logo
9:38 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Sean Paul's Yankees vs Guardians Best Bet

New York Yankees Logo
46183
1:10 PM ET
MLB.TV
Cleveland Guardians Logo
Under 7.5
FanDuel Logo

By Sean Paul

I'm rolling with the Under.

Neither offense has looked good in June, and both pitchers are well above-average.

Matchup-wise, Carlos Rodon should limit some of these Guardians lefties, while Parker Messick has the advantage in matchups against Trent Grisham and Ben Rice — two of the Yankees' most important hitters.

This feels like a classic 3-2 or 2-1 ballgame.

Pick: Under 7.5 (-110 or Better)



Ryan Minion's Reds vs Padres Best Bet

Cincinnati Reds Logo
46183
4:10 PM ET
MLB.TV
San Diego Padres Logo
Padres ML
FanDuel Logo

By Ryan Minion

The Padres and Reds will duke it out on Wednesday in the last of a three-game set at PetCo Park. Michael King will take the mound for San Diego, while Brady Singer will toe the rubber for Cincinnati.

King has been a model of consistency over the past seven seasons, posting a 3.26 ERA and 1.18 WHIP across a vast sample size. He’s actually pitched better than his career statistics indicate, given his outlier 2020 COVID season, where he posted a 7.76 ERA and 1.54 WHIP across 26 innings. He’s recorded a sub-3.50 ERA in every other full season.

Singer is not a model of consistency, running a 5.89 ERA and 1.69 WHIP across his first 12 outings.

Behind a massive starting pitching edge, the Padres should win this game at home.

Pick: Padres ML (-170 or Better)



Sean Zerillo's Phillies vs Blue Jays Best Bet

Philadelphia Phillies Logo
46183
7:07 PM ET
MLB.TV
Toronto Blue Jays Logo
Phillies ML
FanDuel Logo

By Sean Zerillo

I project some value on the Phillies in this game.

While the consensus line sits closer to -155, I project the Phillies as -165 moneyline favorites.

As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab

I grabbed the Phillies ML at -140, and it's unfortunately moved out of range at some books.

If you can get Philadelphia ML at -150 or better, there's enough of an edge against the market to warrant a wager — I always look for at least a 2% projected edge from my numbers to the oddsmakers.

Pick: Phillies ML (-150 or Better)



Tanner McGrath's Astros vs Angels Best Bet

Houston Astros Logo
46183
9:38 PM ET
MLB.TV
Los Angeles Angels Logo
Angels ML
FanDuel Logo

By Tanner McGrath

This game triggered one of our Action PRO betting systems, powered by Evan Abrams:

MLB Icon
Evan Abrams / Bet Labs – Division Momentum: Edge After Blowout
the team's win percentage is between 16% and 75%
the team’s home/away streak is between -6 and 7 games
the closing moneyline is between -135 and 290
the game is a Division game
the team's previous game margin is between 6 and 21
the previous game is a Division game
the game is played during the Regular season
$14,763
WON
947-899-1
RECORD
51%
WIN%

This system backs teams in regular-season division games coming off a dominant win over a divisional opponent, leveraging momentum and familiarity in rivalry spots.

Focusing on teams with win percentages between 16% and 75% avoids both extreme outliers and market darlings.

It targets games where teams are priced between -135 and +290, and have just completed a win by over six runs, indicating a strong recent performance.

Layering in a moderate home/away streak (between six and seven games) and the context of back-to-back division matchups, this strategy aims to exploit situations where public reaction hasn’t fully adjusted to recent blowout results.

Pick: Angels ML (-130 or Better)



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