Bills vs. Panthers Odds & Betting Predictions - October 26, 2025

Bills at Panthers

5:00 pm • FOX
40 - 3

Bills at Panthers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Bills
4-2
-7.5
-7.5-108
o48-110
-395
Panthers
4-3
u46.5
+7.5-112
u48-112
+315
location pinSunday 5:00 p.m.
October 26, 2025
Bank of America StadiumCharlotte
Bills vs. Panthers Expert Picks
Picks Office
Picks Office
Last 30d: 108-91-3 (+10.7u)
Under 46.5 (Live)-110
1u
Forgot to track
Vegas Refund
Vegas Refund
Last 30d: 40-35-1 (+1.4u)
CAR +7.5-112
1.12u
YBK Picks.com
Last 30d: 67-34-3 (+61.0u)
CAR +7-105
2u
Jeremiah Rose
Jeremiah Rose
Last 30d: 35-32-0 (-0.1u)
D.Kincaid o3.5 Recs-127
0.25u
Sandy Plashkes
Sandy Plashkes
Last 30d: 95-104-2 (-3.7u)
J.Allen Anytime TD Scorer Yes+105
1u
Cam Is Money
Cam Is Money
Last 30d: 73-95-3 (-16.7u)
J.Coker o24.5 Rec Yds-110
1u
Ryan Sura
Ryan Sura
Last 30d: 92-104-1 (-11.6u)
J.Allen Anytime TD Scorer Yes+105
1.2u
Brian Bitler
Brian Bitler
Last 30d: 75-67-2 (+12.0u)
CAR +7-102
3u
Derek Carty
Derek Carty
Last 30d: 22-24-0 (+3.1u)
T.Shavers u1.5 Recs+102
1u
There may be some value on the receptions prop for Tyrell Shavers. THE BLITZ is projecting him to record 1.13 receptions, and the oddsmakers are implying 1.94. The model believes there is a 70% chance he records fewer than 1.5 receptions. If you can get the under at +102 or better, there is some great value here. (This play is good down to at least -153.) Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
Babs .
Babs .
Last 30d: 96-100-3 (+0.4u)
A.Dalton o1.5 Rush Yds-105
1u
J.Coker o20.5 Rec Yds-114
1u
Chris Gimino
Chris Gimino
Last 30d: 27-50-1 (-20.2u)
J.Coker o19.5 Rec Yds-118
1u
Nick Giffen
Nick Giffen
Last 30d: 37-65-1 (+0.8u)
A.Dalton o1.5 Rush Att+115
1u
Andy Dalton over 1.5 rush att (+115 at Bet365, +110 at MGM) Dalton has scrambled 7 times on 252 dropbacks as a Panther, which equates to one in every 36 dropbacks. He's projected for 36 dropbacks on the dot, so that's 1 scramble on average right there He's facing a Bills defense that allows QBs to scramble right at their league average rates so far through 6 Bills games, so there doesn't need to be much adjustment there However I'd suspect the long-term scramble rate to be higher given the Bills high pressure rate and use of two-high safety looks, both of which tend to promote more scrambling In his starts as a Panther (to not bias for games when he came in on mop up duty in blowouts and earned kneeldowns at a high rate), Dalton has one rush att for every 18 dropbacks, which would put him at 2 rush attempts. The most likely way he'll run here is with a scramble, and the Panthers are 7-7.5 point underdogs. If that most-likely scenario happens and Carolina is trailing by 1-2 scores for a good chunk of the game, Dalton projects to more like 43 dropbacks which would really help. A designed run/qb sneak isn't out of the question, or even an aborted snap fumble recovery which would count as a run. There's lots of little subtle ways to get an extra carry that all get factored in and add up. Accounting slightly less propensity to scramble/more likely to get sacked at his age, and lower kneel down probability (he could still have a first half kneel and there is a non-zero chance the Panthers win) I'm still getting 1.87 rush attempts which would equate to around a 56% chance to clear 1.5, so getting +115 is nearly a 10% edge.
Allan Lem
Allan Lem
Last 30d: 128-108-5 (+0.8u)
T.Tremble u9.5 Longest Reception-110
0.55u
Tailing @The_Oddsmaker
Sean Koerner
Sean Koerner
Last 30d: 44-35-0 (+4.8u)
T.Tremble u9.5 Longest Reception-110
0.55u
Despite being 7-point underdogs, the Panthers will likely still try to lean on the run against a Bills run-funnel defense, especially with both Chuba Hubbard and Rico Dowdle healthy. Tremble saw a sharp drop in routes last week with Ja’Tavion Sanders returning from a 3-game absence. Rookie Mitchell Evans even ran one more route than him, which further caps his role in the passing game. Add in Jalen Coker’s season debut and Jimmy Horn Jr. establishing a consistent role, and it’s clear Tremble’s passing-game involvement is trending down. His first-read rate drops from 22% (in three games without Sanders) to just 5.2% when Sanders is active. Tremble still plays in early-down and run-heavy personnel, but when he does see a target they are typically just 4-5 yards downfield. The market has already adjusted on his receptions and yardage props, yet the longest reception line remains a bit too high. Even if he catches 1–2 passes underneath, the odds of one going for 10+ yards are less than a coin flip. I’m projecting his median longest catch at 8 yards, giving roughly a 60% chance he stays under 9.5. This is a sneaky prop for the early slate with plenty of other games to distract from this gross/boring prop. Either it quietly cashes with plenty of other games/props going on or you know early if he breaks a 10+ yard catch and run (which my model expects only about 40% of the time).
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 178-156-0 (-0.3u)
Over 23.5 (1H)+105
0.8u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 15-54-1 (-5.8u)
X.Legette Anytime TD Scorer Yes+450
0.5u
D.Knox Anytime TD Scorer Yes+350
0.5u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 59-104-0 (+0.0u)
CAR +320
0.31u
J.Hawes Anytime TD Scorer Yes+625
0.16u
Babs .
Babs .
Last 30d: 96-100-3 (+0.4u)
D.Kincaid o41.5 Rec Yds-114
1u
Gilles Gallant
Gilles Gallant
Last 30d: 28-75-1 (-7.7u)
X.Legette Anytime TD Scorer Yes+450
0.5u
Brandon Anderson
Brandon Anderson
Last 30d: 46-75-0 (+3.8u)
J.Hawes Anytime TD Scorer Yes+1100
0.25u
We were always going to want a tight end against the Panthers on National Tight Ends Day — the question was only which one. Carolina led the league last season with 11 touchdowns allowed to opposing TEs and has already allowed four this season. And these are not superstar TEs; they're such luminaries as Foster Moreau, Ben Sinnott, Nate Adkins, Noah Gray, Grant Calcaterra, Payne Durham, and Hunter Long. You probably don't even recognize some of those names. That's because they're not lead TEs — they're second or third on the depth chart. They're blocking tight ends, sneaking out at the goal line for a red zone touchdown. And so we come to our longest shot TD bet of the day, third-string Bills tight end, Jackson Hawes. It looks like Dalton Kincaid will return from injury, and Dawson Knox is second on the depth chart, but Hawes has impressed as a rookie, especially as a blocker. He ranks No. 2 among all tight ends in PFF grade, buoyed by his excellent blocking grades both run and pass. Hawes typically plays almost half the snaps, though he doesn't see many targets. He's seen just four targets in six games. But three of those four targets came in the red zone, and Hawes has caught all four of them — including his first career touchdown! Let's see if he can find a second on National Tight Ends Day. Hawes is our longest shot of the day at +1100 (Hard Rock).
CAR +320
0.25u
I low-key like this matchup for the Panthers, even as touchdown underdogs. Carolina has an excellent power rushing attack with its one-two punch of Chuba Hubbard and Rico Dowdle, and Buffalo ranks dead last in Run DVOA defensively. Even with Bryce Young out, the Panthers might just pound the rock all game. They may also be able to hold up defensively against Buffalo's power rushing, with the Panthers defense surprisingly ranked No. 3 in Run DVOA defense itself, thanks to a stellar season from Derrick Brown. Home underdogs of 7+ points the first eight games of the season are an incredible 19-2-1 ATS since 2019, covering 95% of the time by 9.6 PPG, and that trend already pointed us toward Browns-Packers and Giants-Eagles upsets this season. I'm sprinkling the Panthers moneyline at +320 (ESPN Bet) — and in a game that could be closer than expected due to the run fits, I'm expecting the Bills to lean in even further and get some extra bodies on the field at tight end to find an advantage in the run game.
Royals Props
Royals Props
Last 30d: 31-19-1 (+8.2u)
T.McMillan o53.5 Rec Yds-118
1.18u
Markus Markets
Markus Markets
Last 30d: 46-31-0 (+21.5u)
K.Shakir o4.5 Recs+109
1u
Boomer Betz
Boomer Betz
Last 30d: 169-160-3 (+12.8u)
R.Dowdle u51.5 Rush Yds-109
1u
J.Allen u32.5 Rush Yds-112
1u
Kenny Ducey
Kenny Ducey
Last 30d: 19-20-1 (-2.9u)
CAR +7.5-115
1.15u
💰🦡 Jake
💰🦡 Jake
Last 30d: 116-129-6 (+3.8u)
CAR +7.5-115
0.58u
CAR +7.5-115
1.15u
Jim Sannes
Jim Sannes
Last 30d: 16-47-0 (-16.5u)
Over 46.5-105
1u
Even with a downgrade in for Andy Dalton, I have this total at 50.6. Panthers' run game should do damage here, and expecting the Bills' offense to be effective off the bye.
Boomer Betz
Boomer Betz
Last 30d: 169-160-3 (+12.8u)
BUF -7.5-111
1u
PX
Matt Moore
Matt Moore
Last 30d: 35-43-0 (-2.6u)
CAR +7.5-115
1.1u
FTN Fantasy
FTN Fantasy
Last 30d: 48-45-1 (+4.8u)
CAR +7.5-115
1u

Bills vs. Panthers Previews & Analysis

  • Bills vs. Panthers: Bounce-Back Spot for Buffalo article feature image

    Bills vs. Panthers: Bounce-Back Spot for Buffalo

    John Lanfranca
    Oct 26, 2025 UTC
  • NFL Player Props: 7 Picks for Sunday's Slate article feature image

    NFL Player Props: 7 Picks for Sunday's Slate

    Action Network Staff
    Oct 26, 2025 UTC
  • Gallant's Anytime TD Picks for Every NFL Game article feature image

    Gallant's Anytime TD Picks for Every NFL Game

    Gilles Gallant
    Oct 26, 2025 UTC
  • National Tight Ends Day TD Picks & Parlays article feature image

    National Tight Ends Day TD Picks & Parlays

    Brandon Anderson
    Oct 26, 2025 UTC
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Bills vs. Panthers Props

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Bills vs. Panthers Public Betting Percentages

Away Logo

Bills

Public

75%

Bets%

25%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Panthers
5-23-02-2N/A5-2
Bills
2-41-31-11-41-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Panthers
4-32-12-2N/A4-3
Bills
3-33-10-22-31-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Panthers
4-3N/AN/AN/A4-3
Bills
4-2N/AN/A3-21-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 19th@NYJW 13-6+1.5 WU 39.5CAR -108
Oct 12thDALW 30-27+3 WO 47CAR +135
Oct 5thMIAW 27-24+1.5 WO 44.5CAR -102
Sep 28th@NEL 13-42+5.5 LO 42.5NE +200
Sep 21stATLW 30-0+4.5 WU 44CAR +185

Bills vs. Panthers Injury Updates

Bills Injuries

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Tyler Bass
    K

    Bass is out with hip

    Out

  • Joshua Palmer
    WR

    Palmer is out with ankle

    Out

Panthers Injuries

  • David Moore
    WR

    Moore is out with elbow

    Out

  • Damarri Mathis
    CB

    Mathis is out with knee

    Out

  • Bryce Young
    QB

    Young is out with ankle

    Out

Team Stats
381
Total Yards
151
49
Total Plays
40
7.8
Yards Per Play
3.8
163
YDS
112
12/19
Comps/Atts
9/16
6.81
YPA
3.429
1/0
TDs/INTs
0/1
2/20
Sacks/Yards
5/40
238
Rush Yards
79
28
Attempts
19
8.5
YPC
4.158
4
TDs
0

Turnovers

0
Fumbles Lost
2
0
Interceptions
1

Efficiency

2/3 66.67%
Redzone
0/1 0%
6/9 0%
3rd Down
4/9 0%
0/0 0%
4th Down
0/0 0%

First Downs

21
Total
11
8
Pass
7
12
Rush
2
1
Penalty
2
5/35
Penalties/Yards
4/20
26:23
Possession
17:18

Bills vs. Panthers Odds Comparison

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Bills at Panthers Team Totals

MatchupOverUnder
Bills
4-2
N/A
N/A
Panthers
4-3
N/A
N/A