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Saints vs. Bills Odds & Betting Predictions - September 28, 2025

Saints at Bills

5:00 pm • CBS

New Orleans Saints

0-3
@

Buffalo Bills

3-0

Saints at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Saints
0-3
+12.5
+15.5-110
o48.5-105
+874
Bills
3-0
u46.5
-15.5-110
u48.5-115
-1450
location pinSunday 5:00 p.m.
September 28, 2025
Highmark StadiumOrchard Park
thermometer image74°Fahrenheit
rain image0%Rain
wind image5Wind
Saints vs. Bills Expert Picks
Jim Sannes
Jim Sannes
Last 30d: 13-36-0 (-2.0u)
Over 48.5-105
1u
Have this total way high due as the Bills should be able to name their score, and I do think the Saints' offense will do at least *something*.
FTN Fantasy
FTN Fantasy
Last 30d: 70-91-0 (-28.9u)
BUF -15.5-110
1u

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Saints vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Saints vs. Bills Public Betting Percentages

Away Logo

Saints

Public

Home Logo

Bills

42%

Bets%

58%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 3-0 in their last 5 games.
  • Bills are 2-1 in their last 5 games against the spread
  • Bills are 1-0 in their road games against the spread
  • The totals have gone OVER in 2 of Bills' last 3 games
  • The totals have gone OVER in 2 of Bills' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		2-11-11-01-11-0
Saints		0-30-20-1N/A0-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		2-12-00-11-11-0
Saints		2-11-11-0N/A2-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		3-0N/AN/A2-01-0
Saints		0-3N/AN/AN/A0-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 19thMIAW 31-21-11.5 LO 50.5BUF -800
Sep 14th@NYJW 30-10-6 WU 47.5BUF -290
Sep 8thBALW 41-40+1.5 WO 51.5BUF +105
Aug 23rd@TBW 23-19-1.5 WO 37.5BUF -125
Aug 18th@CHIL 0-38+2.5 LU 40.5CHI +120

Saints vs. Bills Injury Updates

Saints Injuries

  • Taysom Hill
    TE

    Hill is out with knee

    Out

  • Chase Young
    DE

    Young is out with calf

    Out

  • Trevor Penning
    OL

    Penning is out with toe

    Out

  • Jordan Howden
    DB

    Howden is questionable with oblique

    Questionable

  • Trey Palmer
    WR

    Palmer is questionable with hamstring

    Questionable

  • Devaughn Vele
    WR

    Vele is questionable with hip

    Questionable

Bills Injuries

  • Tyler Bass
    K

    Bass is out with hip

    Out

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Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    755
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    5
    ptd
  • rushing yards
    James Cook logo
    James Cook
    284
    ryds
  • rushing touchdowns
    James Cook logo
    James Cook
    4
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBJosh AllenMitchell TrubiskyShane Buechele
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirElijah MooreStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsTylan GrableChase LundtTravis Clayton
LGDavid EdwardsKendrick Green
CConnor McGovernSedrick Van Pran-Granger
RGO'Cyrus TorrenceAlec Anderson
RTSpencer BrownRyan Van Demark
LDEGreg RousseauLandon JacksonJavon Solomon
WLBMatt MilanoDorian WilliamsKeonta Jenkins
MLBTerrel BernardJoe AndreessenShaq ThompsonJimmy Ciarlo
LCBChristian BenfordMaxwell HairstonDorian Strong
SSCole BishopCam LewisWande Owens
FSTaylor RappDamar HamlinJordan Hancock
RCBTre'Davious WhiteDane JacksonJa'Marcus Ingram
PRBrandon Codrington
KRBrandon CodringtonElijah Moore
LSReid Ferguson
RWRKeon ColemanCurtis SamuelKristian Wilkerson
KTyler Bass
NBTaron JohnsonBrandon Codrington
DTEd OliverT.J. SandersDeWayne Carter
FBReggie Gilliam
LWRJoshua PalmerTyrell Shavers
NTDaQuan JonesDeone WalkerZion Logue
Team Stats

Passing

599
YDS
771
80/121
Comps/Atts
70/101
5.281
YPA
7.792
4/1
TDs/INTs
5/0
6/40
Sacks/Yards
4/16

Rushing

307
Rush Yards
489
79
Attempts
101
3.886
YPC
4.842
1
TDs
7

Turnovers

Fumbles Lost
1
Interceptions
0

Efficiency

5/10 50%
Redzone
10/15 66.67%
14/40 0%
3rd Down
18/40 0%
2/6 0%
4th Down
3/3 0%

First Downs

63
Total
77
36
Pass
39
15
Rush
29
12
Penalty
9

Misc

/
Penalties/Yards
/
Possession

Saints vs. Bills Odds Comparison

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Saints at Bills Team Totals

MatchupOverUnder
Saints
0-3
N/A
N/A
Bills
3-0
N/A
N/A