Saints vs. Bills Odds & Betting Predictions - September 28, 2025

Saints at Bills

5:00 pm • CBS
19 - 31

Saints at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Saints
2-4
+14.5-110
o48.5-108
+800
Bills
5-1
-14.5-110
u48.5-112
-1500
location pinSunday 5:00 p.m.
September 28, 2025
Highmark StadiumOrchard Park
Saints vs. Bills Expert Picks
Stuck 🚨
Stuck 🚨
Last 30d: 69-76-2 (+2.4u)
NO +15.5-110
0.36u
Have to play this grossness smaller with Bills injuries.
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 52-67-0 (+0.5u)
A.Kamara u14.5 Rush Att-125
0.63u
Last week was wild. The Saints lost 44–13, yet Kamara finished with 18 carries. The reason: a ridiculous first half where New Orleans ran 46 plays because Seattle kept scoring fast, including a punt-return TD that handed the ball right back. One drive was 16 plays with 5 Kamara carries, Kendre Miller got the next series and went three-and-out, then Kamara came back for another 10+ play drive with 4 more. They are averaging 68.7 plays per game, tied for the league lead. That kind of volume is due for regression. Now they are +14.5 dogs at Buffalo in what should turn into more of a trailing (2+ scores) pass heavy game script. However, the Bills lead the league in time of possession, and with a 2+ score lead they go at a very slow pace..letting roughly 31 seconds tick between snaps, which suppresses their opponents play volume. I expect Buffalo to get out front, bleed clock, and push the Saints toward more Kamara checkdowns instead of piling up carries. There is also a real chance Kendre Miller eats a bit more early-down work as the season goes as they evaluate for 2026 and beyond; if his occassional series isn’t a 3 and out, that would eat into Kamara’s carry ceiling. I have Kamara at 13.8 rush attempts with about 60% to stay under 14.5. This is about the number. Getting exposure to 14 is meaningful, roughly worth ~10%, while 13.5 would be a true coin flip.
Doug Ziefel
Doug Ziefel
Last 30d: 416-413-9 (+32.4u)
E.Moore o10.5 Rec Yds-110
0.55u
J.Allen u1.5 Pass TDs+130
0.38u
BUF -15.5-110
0.55u
Jeremiah Rose
Jeremiah Rose
Last 30d: 55-65-3 (-3.2u)
J.Palmer o1.5 Recs-140
0.14u
J.Allen o5.5 Rush Att-140
0.14u
Ryan Minion
Ryan Minion
Last 30d: 244-229-3 (+28.9u)
C.Olave Anytime TD Scorer Yes+250
$2.50
OldSchool0909
Last 30d: 51-59-1 (-3.4u)
BUF -15.5-110
1u
Collin Whitchurch
Collin Whitchurch
Last 30d: 116-164-3 (-2.1u)
J.Allen u6.5 Rush Att+105
0.5u
Sandy Plashkes
Sandy Plashkes
Last 30d: 113-112-4 (+23.5u)
A.Kamara o19.5 Rec Yds-116
1.16u
Brandon Anderson
Brandon Anderson
Last 30d: 37-109-0 (-7.8u)
BUF o29.5 Team Total-170
0.5u
The Degenerates
The Degenerates
Last 30d: 57-56-2 (-2.4u)
BUF -15.5 (Live)-108
1.08u
Brian Bitler
Brian Bitler
Last 30d: 72-80-4 (-20.3u)
NO +14.5-105
2.86u
Gilles Gallant
Gilles Gallant
Last 30d: 24-66-1 (-3.7u)
C.Olave Anytime TD Scorer Yes+275
1.38u
Nick Giffen
Nick Giffen
Last 30d: 46-138-0 (-3.5u)
J.Allen u6.5 Rush Att+105
1u
Josh Allen under 6.5 rush att MGM/365 NO 5th worst pressure rate vs. expected so far in 2025 and 5th worst raw pressure rate Josh Allen scramble rate has decreased by more than 10% with a clean pocket than facing pressure since the start of last year The Saints also play zone at a top-six rate in the NFL, including Cover 3 at the third-highest rate which is the hardest to scramble against with an extra man in the box and zone coverage with the DBs facing the QB As huge faves, likely won’t be asked to do much designed w/legs Might get a couple kneel downs, but with a strong chance of a blowout, it would be Trubisky taking the knees in that scenario. Since start of last year: Trubisky has taken all the 2H kneels in double-digit BUF wins Allen has taken all the 2H knees in single-digit BUF wins Trubisky with 18 2H kneels across 8 games, Allen with 12 2H kneels across 6 games
NO +15.5-115
1u
Luck Rankings
Allan Lem
Allan Lem
Last 30d: 46-35-1 (+0.9u)
J.Allen u6.5 Rush Att+105
0.48u
Tailing @nick_giffen
Topper
Topper
Last 30d: 160-148-8 (+5.3u)
NO +15.5-110
0.91u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 46-113-0 (-8.5u)
BUF o29.5 Team Total-170
0.59u
Mjaybrod
Mjaybrod
Last 30d: 56-77-1 (-22.9u)
A.Kamara o19.5 Rec Yds-110
1u
Tailing @moneyplayzz
Cam Is Money
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
R.Davis o17.5 Rush Yds-104
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 100-108-1 (+23.9u)
J.Palmer Anytime TD Scorer Yes+295
0.1u
New Owner
New Owner
Last 30d: 0-0-0 (+0.0u)
S.Rattler u211.5 Pass Yds-135
0.74u
Derek Carty
Derek Carty
Last 30d: 21-22-0 (+3.4u)
T.Johnson u3.5 Rush Att+125
1.25u
THE BLITZ is forecasting 2.88 rush attempts for Ty Johnson compared to 5.00 rush attempts implied by sportsbooks, so I believe there is some value here. If you take the under, you’d be projected to win 63% of the time, resulting in a 47% ROI. Based on a $100 wager, the expected value here would be $47.39. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz

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Saints vs. Bills Props

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Saints vs. Bills Public Betting Percentages

Away Logo

Saints

Public

30%

Bets%

70%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills
4-22-12-13-21-0
Saints
3-30-33-00-22-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills
5-12-13-04-11-0
Saints
4-22-12-12-01-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills
5-1N/AN/A4-11-0
Saints
2-4N/AN/A0-21-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 19thMIAW 31-21-11.5 LO 50.5BUF -800
Sep 14th@NYJW 30-10-6 WU 47.5BUF -290
Sep 8thBALW 41-40+1.5 WO 51.5BUF +105
Aug 23rd@TBW 23-19-1.5 WO 37.5BUF -125
Aug 18th@CHIL 0-38+2.5 LU 40.5CHI +120

Bills vs. Saints Injury Updates

Bills Injuries

    Saints Injuries

    • Travis Etienne
      RB

      Etienne is out with hamstring

      Out

    • Jordyn Tyson
      WR

      Tyson is out with hamstring

      Out

    Team Stats
    298
    Total Yards
    356
    65
    Total Plays
    57
    4.6
    Yards Per Play
    6.2
    126
    YDS
    209
    18/28
    Comps/Atts
    16/22
    3.516
    YPA
    7.64
    1/1
    TDs/INTs
    2/1
    3/17
    Sacks/Yards
    3/18
    189
    Rush Yards
    165
    34
    Attempts
    32
    5.559
    YPC
    5.156
    1
    TDs
    2

    Turnovers

    0
    Fumbles Lost
    0
    1
    Interceptions
    1

    Efficiency

    2/4 50%
    Redzone
    2/3 66.67%
    5/13 0%
    3rd Down
    3/10 0%
    0/2 0%
    4th Down
    0/1 0%

    First Downs

    22
    Total
    20
    7
    Pass
    10
    14
    Rush
    9
    1
    Penalty
    1
    4/41
    Penalties/Yards
    11/55
    28:39
    Possession
    31:21

    Saints vs. Bills Odds Comparison

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    Saints at Bills Team Totals

    MatchupOverUnder
    Saints
    2-4
    N/A
    N/A
    Bills
    5-1
    N/A
    N/A