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Saints vs. Bills Odds & Betting Predictions - September 28, 2025

Saints at Bills

5:00 pm • CBS
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New Orleans Saints

0-1
@

Buffalo Bills

1-0

Saints at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Saints
0-1
N/A
N/A
N/A
Bills
1-0
N/A
N/A
N/A
location pinSunday 5:00 p.m.
September 28, 2025
Highmark StadiumOrchard Park

Saints vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Saints vs. Bills Public Betting Percentages

Away Logo

Saints

Public

Home Logo

Bills

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 1-0 in their last 5 games.
  • Bills are 1-0 in their last 5 games against the spread
  • The totals have gone OVER in 1 of Bills' last 1 games
  • The totals have gone OVER in 1 of Bills' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		1-01-0N/AN/A1-0
Saints		0-10-1N/AN/A0-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		1-01-0N/AN/A1-0
Saints		0-10-1N/AN/A0-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		1-0N/AN/AN/A1-0
Saints		0-1N/AN/AN/A0-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 8thBALW 41-40+1.5 WO 51.5BUF +105
Aug 23rd@TBW 23-19-1.5 WO 37.5BUF -125
Aug 18th@CHIL 0-38+2.5 LU 40.5CHI +120
Aug 9thNYGL 25-34-2.5 LO 37.5NYG -155
Jan 26th@KCL 29-32+1.5 LO 49.5KC -105

Saints vs. Bills Injury Updates

Saints Injuries

  • Taysom Hill
    TE

    Hill is out with knee

    Out

  • Chase Young
    DE

    Young is out with calf

    Out

  • Trevor Penning
    OL

    Penning is out with toe

    Out

  • Jordan Howden
    DB

    Howden is questionable with oblique

    Questionable

Bills Injuries

  • Tre'Davious White
    CB

    White is doubtful with groin

    Doubtful

  • Tyler Bass
    K

    Bass is out with hip

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    394
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    2
    ptd
  • rushing yards
    James Cook logo
    James Cook
    44
    ryds
  • rushing touchdowns
    Josh Allen logo
    Josh Allen
    2
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJosh AllenMitchell TrubiskyShane Buechele
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirElijah MooreStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsTylan GrableChase LundtTravis Clayton
LGDavid EdwardsKendrick Green
CConnor McGovernSedrick Van Pran-Granger
RGO'Cyrus TorrenceAlec AndersonDan Feeney
RTSpencer BrownRyan Van Demark
LDEGreg RousseauLandon JacksonJavon Solomon
WLBMatt MilanoDorian WilliamsKeonta Jenkins
MLBTerrel BernardJoe AndreessenShaq ThompsonJimmy Ciarlo
LCBChristian BenfordMaxwell HairstonDorian Strong
SSCole BishopCam LewisWande Owens
FSTaylor RappDamar HamlinJordan Hancock
RCBTre'Davious WhiteDane JacksonJa'Marcus Ingram
PRBrandon Codrington
KRBrandon CodringtonElijah Moore
LSReid Ferguson
LWRJoshua PalmerTyrell Shavers
KTyler Bass
RWRKeon ColemanCurtis SamuelKristian Wilkerson
FBReggie Gilliam
DTEd OliverT.J. SandersDeWayne Carter
NTDaQuan JonesDeone WalkerZion Logue
NBTaron JohnsonBrandon Codrington
Team Stats

Passing

208
YDS
389
27/46
Comps/Atts
33/46
4.652
YPA
8.565
0/0
TDs/INTs
2/0
1/6
Sacks/Yards
1/5

Rushing

107
Rush Yards
108
22
Attempts
31
4.864
YPC
3.484
1
TDs
3

Turnovers

Fumbles Lost
0
Interceptions
0

Efficiency

1/4 25%
Redzone
5/7 71.43%
5/14 0%
3rd Down
7/15 0%
1/2 0%
4th Down
1/1 0%

First Downs

21
Total
29
12
Pass
18
5
Rush
9
4
Penalty
2

Misc

/
Penalties/Yards
/
Possession

Saints vs. Bills Odds Comparison

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Saints at Bills Team Totals

MatchupOverUnder
Saints
0-1
N/A
N/A
Bills
1-0
N/A
N/A