The San Francisco 49ers visit the Seattle Seahawks in the NFC Divisional Round on Saturday, January 17. Kickoff from Lumen Field in Seattle, Washington, is set for 8:00 p.m. ET. 49ers vs Seahawks will broadcast on FOX.
The Seahawks are 7-point favorites over the 49ers on the spread (Seahawks -7), with the over/under set at 45 total points. Seattle is a -330 favorite to win outright on the moneyline, while San Francisco is +265 to pull off the upset.
Below, you can find our 49ers vs Seahawks picks for the NFC Divisional Round, which include predictions for the spread, game total and three player props.
49ers vs Seahawks Picks & Predictions
| Game | Time (ET) | Best Bet |
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  | 8 p.m. | |
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| 8 p.m. | |
| 8 p.m. | |
| 8 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
49ers vs Seahawks Odds
- 49ers vs Seahawks Moneyline: 49ers +265, Seahawks -330
- 49ers vs Seahawks Spread: 49ers +7, Seahawks -7
- 49ers vs Seahawks Total: 45
NFL odds for the Divisional Round via bet365
49ers vs Seahawks Spread Prediction
The 49ers mustered just 173 yards of offense against Seattle two weeks ago in Week 18 when they squared off for the NFC’s top seed, and they are in a much tougher spot heading into this game on Saturday night.
Brock Purdy has been relying on explosive plays in the passing game, and no team in the NFL limits chunk gains better than the Seahawks.
Seattle surrenders the league’s lowest yards per pass attempt. That number is stable even when they don’t pressure the opposing passer. This is the reason Purdy’s depth of target was below five yards on average in their Week 18 contest.
The loss of George Kittle is another major obstacle the passing attack will have to overcome if the 49ers are going to have more success than they did just 14 days ago.
Sam Darnold didn’t have a strong finish to the season, but he still had a very efficient performance against San Francisco in Week 18, completing 77% of his attempts.
The 49ers' pass rush is non-existent, finishing 30th in pressure rate this season. Darnold should be comfortable in the pocket as he scans the field and exploits the voids in the Niners’ secondary.
Don’t be fooled by the 49ers' defensive performance a week ago against an Eagles offense with a number of major issues.
Seattle will hold serve at home and win with a margin behind the havoc created by their elite defense.
Pick: Seahawks -7 (-110)
49ers vs Seahawks Over/Under Pick
By Billy Ward
Your mileage may vary by the time you see this, but at the time of writing, the total in the rubber match between the Seahawks and 49ers is as high as 45.5 at DraftKings.
These teams have met twice already this season, combining for just 46 points in both games.
While past performance doesn’t guarantee future results, that’s a pretty big number considering how the two previous games have gone. Especially considering that rematches tend to produce lower scoring than prior meetings, as defenses adjust to the opposing team.
On top of that, the 49ers are again without George Kittle, and could be missing Ricky Pearsall as well, making their offense heavily reliant on Christian McCaffrey.
While there are certainly worse players to lean on, Christian McCaffrey rushed for just 92 yards on 30 carries in their two previous matchups and is averaging less than four yards per carry overall.
While Seattle probably could put up points against a bad 49ers defense, they’re content to run the ball and slow the game down when playing with a lead, which is very likely given their -7 spread.
While I’d still take the 45s at low juice, I’m prioritizing the 45.5 line at DraftKings, which is currently at -118.
Pick: Under 45.5 (-118)
49ers vs Seahawks Player Props: Sam Darnold
This line is a bit low given the spot. The 49ers' pass defense has been one of the league's worst in the second half of the season and ranks near the bottom of the league in pressure rate.
The 49ers are bottom five in opponent completion percentage this season, sitting at 67.53% and dead last on the road (70.54%).
Seahawks QB Sam Darnold has hit the over at this number in five of the last six games, and even with Seattle being a 7-point favorite, there is still a good chance Darnold will be throwing late in the game as the 49ers' offense can put up a lot of points regardless of the matchup.
The Seahawks have been one of the most run-heavy teams in the league this season, but they've been more pass-heavy in the second half of the season.
I have Darnold projected to hit the over at this number at a 57% clip, making this a great bet at plus odds.
Pick: Sam Darnold Over 19.5 Completions (+101)
49ers vs Seahawks Player Props: Kenneth Walker
This line is far too low for Kenneth Walker.
The Seahawks running back has been a lot more involved in the receiving game in the second half of the season, with 3+ targets in six of the last eight games, and he's hit the over at this number in five of the last eight games despite Seattle having large leads in several of those games.
The 49ers' pass defense is well below average and has been particularly poor against RBs (allowing the 3rd-most targets).
San Francisco is near the bottom of the league in both blitz rate and pressure rate, which should force more dump-offs to Walker in the flat when guys are covered downfield.
Walker just had 36 receiving yards off of four targets against this same team two weeks ago. I have him projected for eight yards over this number, making this a great bet.
Pick: Kenneth Walker Over 11.5 Receiving Yards (-110)
49ers vs Seahawks Player Props: Christian McCaffrey
By Chris Raybon
As noted above Christian McCaffrey hasn't been very efficient on the ground this season — but I like him to log over 6.5 receptions.
It’s a little dicey, but I expect McCaffrey to get double-digit targets because Seattle has been really good against WR1s by DVOA, so the 49ers would probably turn to McCaffrey a lot in that case.
McCaffrey has had at least seven receptions of 1-of-2 games against the Seahawks this season — he had six receptions in the one game he went under.
Pick: Christian McCaffrey Over 6.5 Receptions (+120)
