49ers vs. Rams Betting Odds, Picks & Predictions

49ers vs. Rams Betting Odds, Picks & Predictions article feature image
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Kirby Lee-USA TODAY Sports. Pictured: Jared Goff

  • Should the Los Angeles Rams be favored by more than three points at home against the San Francisco 49ers?
  • Check out all of our betting coverage for the matchup, including expert picks, projected odds, pick'em pool recommendations and more.

49ers at Rams Betting Odds, Picks & Predictions

  • Odds: Rams -3
  • Over/Under: 50.5
  • Kickoff: 4:05 p.m. ET
  • TV Channel: FOX

Odds as of Sunday morning and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).


Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full story here.

This is a textbook buy low/sell high spot offering line value in the weekly overreaction game we see play out in the NFL each week.

After starting 2-0, the Rams looked ugly in Cleveland on national TV and then dropped two in a row — one as a home favorite against Tampa Bay and then last Thursday night against Seattle in a game they should’ve won if Greg Zuerlein makes a kick he generally makes.

See our full betting breakdown for 49ers-Rams.

Our Favorite Bets for Sunday’s Main Slate

Our staff breaks down how they’re betting the 1 and 4 p.m. ET games. See their favorite picks.

Sean Koerner’s Projected 49ers-Rams Odds

Sean Koerner uses his NFL Power Ratings to project a spread and total for every game. See whether he thinks either are worth a bet in this matchup.

Pick ‘Em Confidence Rating

Sean Koerner ranks every straight-up and against-the-spread pick for pools in his Pick ‘Em Confidence Ratings. You can even create custom ATS ratings based on the specific spreads your league is using.

See where the Rams and 49ers rank.

Survivor Pool Recommendations

Five weeks down. Twelve to go. Should you roll with Los Angeles or San Francisco in Week 6? Our NFL simulations reveal the best survivor pool picks.

Week 6 Fantasy Football Rankings

Our trio of experts are obsessively updating their fantasy football rankings so you can set your lineups with confidence. Here’s how they rank QBs, RBs, WRs, TEs and Flex players for PPR, standard and half PPR leagues.