The San Francisco 49ers (7-1) and Dallas Cowboys (4-5) will face off in NFL Week 10. Kickoff is set for 4:25 p.m. ET from AT&T Stadium in Arlington, Texas. The game will broadcast live on FOX.
The 49ers are 4.5-point favorites over the Cowboys on the spread, with the over/under set at 55.5. San Francisco is a -210 favorite on the moneyline while Dallas is a +176 underdog.
Let's get into my 49ers vs Cowboys predictions for Sunday, November 15.
49ers vs Cowboys Prediction
- 49ers vs Cowboys pick: Cowboys +4.5 (-120)
My 49ers vs. Cowboys best bet is Dallas to cover the spread. Make sure to find the best odds by checking our live NFL odds page.
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49ers vs Cowboys Odds
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4.5 +100 | 55.5 -115o / -105u | -210 |
| Cowboys Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4.5 -120 | 55.5 -115o / -105u | +176 |
- 49ers vs Cowboys Spread: 49ers -4.5, Cowboys +4.5
- 49ers vs Cowboys Over/Under: 55.5
- 49ers vs Cowboys Moneyline: 49ers -210, Cowboys +176
49ers vs Cowboys NFL Week 10 Preview
San Francisco 49ers Betting Preview: Fool's Gold?
I am still not fully buying into the 49ers defense, which wildly benefited last week against the Raiders from two miraculous fumbles at the one-yard line that erased 14 points off the board.
The 49ers enter this game banged up in the secondary, missing both starting cornerbacks with their nickel corner also listed as questionable.
More importantly, the 49ers offense is not the same juggernaut without Mike Evans, who leads the NFL with an absurd 1.022 EPA per target — the gap between him and the rest of the league is staggering. San Francisco is exercising caution with the veteran as he deals with Achilles tendinitis.
Without Evans on the field, Brock Purdy's average air yards plummet to 35th in the NFL, and he has thrown three interceptions over his last two games.
San Francisco is also due for red-zone regression as it is currently scoring touchdowns at an unsustainable clip of 88%.
Dallas Cowboys Betting Preview: Lookin' Good on D
This matchup presents my biggest numbers edge of NFL Week 10 as my personal power ratings make this spread closer to 49ers -2.9.
The Cowboys defense is flying under the radar, vastly improving since defensive assistant Mike Pettine helped tweaked their scheme. They are generating consistent pressure up front, largely because Quinnen Williams has been a game-wrecker on the interior. He leads all defensive linemen in pressures over the last month.
Dallas has also benched players who are liabilities when it comes to run-stuffing, in addition to utilizing Caleb Downs as a dynamic chess piece all over the field. Getting Joey Porter Jr. back at corner would also be a massive boost.
The only major concern is the absence of P.J. Locke (concussion), which forces Markquese Bell into a larger role. Overall, however, this team's defensive trajectory is pointing way up and a far cry from how the season started .
49ers vs Cowboys Prediction, Betting Analysis
The 49ers are overvalued in the market due to their soft schedule of opposing offenses and extreme luck in the red zone.
With Mike Evans sidelined and the 49ers' secondary in shambles, the Cowboys have more than enough offensive firepower to keep this within a field goal.
I'll take the points with Dallas here.
Pick: Cowboys +4.5 (-120)
