Giants vs. Rams Odds & Betting Predictions - September 22, 2026

Giants at Rams

12:15 am • ABC/ESPN
6 - 28

Giants at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Giants
3-1
+8.5
+6.5-105
o47.5-108
+240
Rams
2-2
u48.5
-6.5-108
u47.5-112
-300
location pinTuesday 12:15 a.m.
September 22, 2026
SoFi StadiumInglewood
Giants vs. Rams Expert Picks
Tyler Shoemaker
Tyler Shoemaker
Last 30d: 81-105-1 (-17.8u)
Under 48.5-126
2u
NYG +7.5-137
1.2u
Bet What Happens Live!
Bet What Happens Live!
Last 30d: 18-42-0 (-10.8u)
M.Stafford o1.5 Int (Live)+400
0.25u
LIVE BET
I.Likely Anytime TD Scorer Yes (Live)+600
0.25u
LIVE BET
M.Nabers Anytime TD Scorer Yes (Live)+550
0.25u
LIVE BET
D.Allen Anytime TD Scorer Yes (Live)+3000
0.1u
LIVE BET
M.Nabers o22.5 Rec Yds (Live)-115
1.15u
LIVE BET
D.Adams o165.5 Rec Yds (Live)-114
1u
LIVE BET
K.Williams o53.5 Rush Yds (Live)-118
1u
LIVE BET
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
Over 0.5 (Live)-106
0.91u
J. Dart early exit. Kalshi won’t refund, but TD, 2+ and o33.5 all back in the wallet. Adjusting
Bet What Happens Live!
Bet What Happens Live!
Last 30d: 18-42-0 (-10.8u)
D.Singletary o10.5 Rush Yds (Live)-128
1.28u
LIVE BET
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
M.Stafford o1.5 Int (Live)+400
0.13u
M.Nabers Anytime TD Scorer Yes (Live)+550
0.1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
M.Nabers Anytime TD Scorer Yes (Live)+630
0.15u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
I.Likely Anytime TD Scorer Yes (Live)+600
0.1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
I.Likely Anytime TD Scorer Yes (Live)+600
0.15u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
D.Allen Anytime TD Scorer Yes (Live)+3000
0.1u
M.Fields o23.5 Rec Yds (Live)-118
0.5u
D.Adams o165.5 Rec Yds (Live)-114
0.5u
K.Williams o53.5 Rush Yds (Live)-118
0.5u
D.Singletary o10.5 Rush Yds (Live)-128
0.64u
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
D.Mooney Anytime TD Scorer Yes (Live)+1100
0.1u
Stuck 🚨
Stuck 🚨
Last 30d: 71-71-3 (-0.1u)
NYG +21.5 (Live)-119
0.09u
Small middle shot with no Puka. Jameis good for a drive or two at some point
Mjaybrod
Mjaybrod
Last 30d: 54-77-1 (-20.1u)
LA o27.5 (Live)-107
1.87u
NFL POD (forgot to add)
OldSchool0909
Last 30d: 73-103-2 (-30.3u)
LA -13.5 (Live)-120
2.08u
Sandy Plashkes
Sandy Plashkes
Last 30d: 100-78-3 (+44.7u)
LA o27.5-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 74-88-0 (-1.8u)
C.Parkinson Anytime TD Scorer Yes+250
0.6u
K.Williams o63.5 Rush Yds-115
1u
Under 23.5 (1H)-104
1.5u
M.Stafford o0.5 Rush Yds+172
0.75u
A.Donald To Record 1+ Sacks Yes+158
0.75u
Mike McNamara
Mike McNamara
Last 30d: 58-65-1 (-2.4u)
Under 47.5-110
0.27u
Chris Gimino
Chris Gimino
Last 30d: 0-1-0 (-0.5u)
B.Corum Anytime TD Scorer Yes+200
0.5u
Vegas Refund
Vegas Refund
Last 30d: 30-32-2 (-5.6u)
LA -6.5-108
1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
C.Parkinson 2+ TDs Yes+2900
0.1u
T.Ferguson 2+ TDs Yes+2800
0.1u
J.Dart 2+ TDs Yes+3300
0.1u
J.Dart 50+ Rushing Yards Yes+280
0.2u
J.Dart o33.5 Rush Yds-113
0.56u
YBK Picks.com
Last 30d: 45-41-0 (+3.2u)
NYG +6.5-105
2u
Collin Whitchurch
Collin Whitchurch
Last 30d: 82-112-2 (-2.3u)
I.Likely Anytime TD Scorer Yes+450
0.25u
Prop Bomb 🏝
Prop Bomb 🏝
Last 30d: 18-18-0 (+1.7u)
C.Skattebo u52.5 Rush Yds-112
0.5u
I'm not looking to overreact to what the Giants did against Dallas in Week 1. The offensive line played extremely well in that game, but I still view this as an average at best unit, and I think this is a much tougher matchup for them up front. The Rams got gashed by San Francisco in Australia last week, but I'm not willing to completely throw out my preseason evaluation of this run defense, even without Myles Garrett. This under has the exact type of outs I'm looking for when fading a primary running back: a matchup disadvantage, poor game script, an expanded backfield rotation, and a lack of explosiveness. All of which make 51.5 to 52.5 a pretty high number for a player with this many paths to going under.
Collin Whitchurch
Collin Whitchurch
Last 30d: 82-112-2 (-2.3u)
T.Ferguson u34.5 Rec Yds+116
0.5u
D.Zvada o5.5 Kicking Pts-114
0.25u
Nick Giffen
Nick Giffen
Last 30d: 40-64-0 (+2.5u)
D.Zvada o5.5 Kicking Pts-114
1u
Projecting 6.93, @The_Oddsmaker projects 6.71
Tyler Shoemaker
Tyler Shoemaker
Last 30d: 81-105-1 (-17.8u)
Under 48-115
1u
Babs .
Babs .
Last 30d: 60-48-1 (+5.2u)
I.Likely u44.5 Rec Yds-111
1.2u
Austin Pendergrass
Austin Pendergrass
Last 30d: 55-41-0 (+8.6u)
C.Skattebo o13.5 Rush Att-102
0.5u
Expect this to be another lower scoring game which means more runs for Skattebo. If week 1 tells us anything, Harbaugh is gonna want to grind out games with the run game and he’s the clear RB1 in the run game. Had 18 carries week 1 so clearly they want to feature him even if he’s not really involved in the pass game
Player Prop Savant
Player Prop Savant
Last 30d: 93-68-0 (+22.6u)
J.Dart o19.5 Pass Comp-125
1.88u
Charlie DiSturco
Charlie DiSturco
Last 30d: 98-148-0 (+24.4u)
T.Ferguson Anytime TD Scorer Yes+260
0.65u
C.Parkinson Anytime TD Scorer Yes+295
0.25u
J.Dart Anytime TD Scorer Yes+338
0.25u
MNF 30% boost
Bet Labs
Bet Labs
Last 30d: 11-13-0 (-3.9u)
LA -6.5-110
1u
Derek Carty
Derek Carty
Last 30d: 29-55-5 (-14.6u)
B.Corum u0.5 Recs+163
1u
There may be some value on the receptions prop for Blake Corum. THE BLITZ is projecting him to record 0.58 receptions, and the oddsmakers are implying 1.05. The model believes there is a 57% chance he records fewer than 0.5 receptions. If you can get the under at +163 or better, there is some great value here. This play is good down to at least +103. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
T.Higbee u1.5 Recs-114
0.5u
B.Corum u0.5 Recs+150
0.33u
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 48-52-0 (-9.1u)
Under 47.5-110
1u
Alex Hinton
Alex Hinton
Last 30d: 80-90-4 (-8.5u)
D.Singletary o1.5 Recs+124
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 100-78-3 (+44.7u)
C.Parkinson o28.5 Rec Yds-108
2.16u
PredictionPro
PredictionPro
Last 30d: 12-14-0 (-4.0u)
NYG +7.5-125
1u
NYG +7.5-120
1u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
M.Nabers o59.5 Rec Yds+104
0.48u
Boost
OldSchool0909
Last 30d: 73-103-2 (-30.3u)
NYG +0.5 (1Q)-118
1u
NYG +3.5 (1H)+100
1u
D.Singletary o6.5 Rec Yds-128
1u
B.Corum o3.5 Rec Yds-102
0.98u
P.Nacua u80.5 Rec Yds-114
1u
B.Corum o47.5 Rush Yds-113
0.88u
K.Williams u63.5 Rush Yds-113
1u
B.Corum o13.5 Longest Rush-114
0.88u
M.Nabers o62.5 Rec Yds-113
1u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
M.Fields o2.5 Recs+125
0.4u
M.Stafford u39.5 Longest Completion-110
0.55u
M.Stafford u21.5 Pass Comp-125
0.63u
Collin Whitchurch
Collin Whitchurch
Last 30d: 82-112-2 (-2.3u)
M.Stafford u21.5 Pass Comp-106
0.27u
Allan Lem
Allan Lem
Last 30d: 41-33-1 (-0.1u)
M.Stafford u21.5 Pass Comp-106
0.53u
Tailing @The_Oddsmaker
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 41-44-0 (+0.5u)
M.Stafford u21.5 Pass Comp-106
0.53u
Stafford always has a pretty high floor in this market. He doesn’t scramble much, avoids sacks, and is one of the best pure passers we’ve ever seen. The market has 18 seasons of evidence telling us that, so this isn’t some “Stafford sucked in Week 1, let’s fade him again” angle. It’s actually the opposite. I think there are a bunch of ways the Rams offense can play well tonight and still help this under. With Puka Nacua looking likely to sit, I expect the Rams to lean a little more on the run. They were at a ridiculous -12.3% PROE in the opener, and there’s no way in hell I’m projecting them to be that run heavy again, but I’m still only around +2% PROE tonight. Ideally Kyren Williams and Blake Corum are ripping off chunk gains and keeping Stafford’s volume down. When Stafford does throw, I’d expect more downfield looks to Davante Adams and Terrance Ferguson. The clown car WR group behind Puka is also pretty ugly. Jordan Whittington, who would’ve been the most natural short-area replacement, is doubtful. Konata Mumpfield could inherit some of that role, but I don’t expect Stafford to pepper him with targets. Xavier Smith, Tutu Atwell and CJ Daniels all profile more as downfield/big-play options. And that’s actually perfect for this bet. We’re totally fine with Stafford completing deep passes. A 20+ yard completion advances the offense quickly, shortens the drive and can put the Rams in position to score. A long TD is even better because the drive ends immediately and a Rams lead encourages more rushing. The Giants also committed a league-high four defensive pass interference penalties last week. DPI on a deep shot is basically the dream outcome here: all the field-position benefit of a completion without adding one to Stafford’s total. That’s also why I always laugh when people say unders mean rooting for “nothing to happen.” You’re rooting for very specific things. Efficient runs. Chunk passes. DPI. Short drives. Touchdowns. Long Giants possessions that bleed clock. There’s plenty going on. The Giants should be fairly run heavy themselves, which can keep Stafford standing on the sideline and lower the overall play volume. I think both teams could approach this game in a way that naturally suppresses total snaps, and completion props are directly tied to that. I have Stafford closer to 20.8 completions with around a 58% chance to stay under 21.5, but I think a lot of the underlying factors lean even more toward the under than that raw projection shows. With Puka’s status creating so many moving pieces in the other markets, this is my Prop of the Game. The rooting guide is pretty simple: Rams run game humming, Stafford pushing the ball downfield when he does throw, LA getting ahead early, and the Giants putting together long clock-killing drives on the other side.
Brian Condon
Brian Condon
Last 30d: 0-2-0 (-3.1u)
NYG +6.5-104
2.08u
Topper
Topper
Last 30d: 186-171-8 (+5.5u)
Under 47.5-109
0.92u
Extended Rest Unders Overall: 185-137-6,57% (ROI:10%) Season:0-0-0, 0% (ROI: 0%) Night Unders Overall: 204-146-5,58% (ROI:12%) Season:0-2-0,0% (ROI:-100%) #TSA
LA -6.5-115
0.87u
Fade the ATS Streak 2.0 Overall: 301-217-15,58% (ROI:13%) Season:2-3-0,40% (ROI:-24%) #TSA
Grant Neiffer
Grant Neiffer
Last 30d: 32-101-4 (+6.5u)
D.Mooney Anytime TD Scorer Yes+940
0.1u
I.Likely Anytime TD Scorer Yes+300
0.25u
The Pick Don
The Pick Don
Last 30d: 8-7-0 (+0.3u)
LA -6.5-115
1.5u
This is NFL overreaction week, and we’re looking to take advantage by backing the Rams at a discounted number. The Giants are coming off an emotional divisional game at home against one of their biggest rivals in an electric atmosphere. They must now travel across the country for a completely different challenge, making this a big time letdown spot for New York. Meanwhile, the Rams return home after being humiliated in Australia. Their performance was undeniably poor, but we don’t believe it accurately reflected the quality of this team. We still have Los Angeles rated as one of the NFL’s best teams, and we’re not allowing one ugly result to drastically change our evaluation. Our model agrees, projecting the Rams to win by 10.14 points. That gives us a fair spread of Rams -10.14 and nearly four points of value at the current line of -6.5. The Giants now have to face an angry Sean McVay, who should have his team prepared and motivated to make a statement. Getting Aaron Donald back provides a major boost to a defense looking to respond. The absences of Puka Nacua and Myles Garrett certainly hurt, but the Rams still have plenty of talent, and McVay remains one of the best coaches and offensive minds in football. “Bouncing back after a loss” can be an overused betting narrative, but McVay has consistently delivered in this situation. His teams have covered 63% of the time following a loss. The Rams will also have nearly three additional days of rest compared to the Giants, giving them another meaningful preparation advantage. This is an ideal response spot for Los Angeles and a difficult emotional, travel and scheduling spot for New York. We expect the Rams to remind everyone why they remain one of our highest rated teams. Give me the Rams -6.5.
Kyle Murray
Kyle Murray
Last 30d: 145-133-7 (+11.8u)
Under 9.5 (1Q)-102
1u
K.Williams o15.5 Rec Yds-114
1.14u
T.Ferguson o2.5 Recs+110
1.1u
D.Adams Anytime TD Scorer Yes-115
1u
M.Nabers o60.5 Rec Yds-125
1.25u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
T.Johnson Anytime TD Scorer Yes+850
0.06u
T.Ferguson Anytime TD Scorer Yes+265
0.5u
D.Mooney o1.5 Recs+120
0.5u
Jaxson Dart 5+ 1Q rushing yards -106
0.53u
I.Likely u4.5 Recs-125
0.63u
M.Stafford o32.5 Pass Att-107
0.54u
Gilles Gallant
Gilles Gallant
Last 30d: 25-46-1 (+9.6u)
T.Johnson Anytime TD Scorer Yes+900
0.2u
T.Ferguson Anytime TD Scorer Yes+350
1.05u
samuelsfarley
samuelsfarley
Last 30d: 20-13-0 (+8.6u)
K.Williams o14.5 Rec Yds-111
$1.00
Williams has had 15+ rec yards in seven straight games and averaged 8.0 yards per catch in W1. With the Giants D letting Williams average 6.2 yards per catch, for 31 yards, we should see Williams cover this line easily.
J.Dart o213.5 Pass Yds-114
$1.00
Dart was hugely efficient in W1, passing for 230 yards in the win over the Cowboys, his EPA/play was the highest of any QB in W1. With Myles Garrett returning and Aaron Donald having only just unretired, the Rams pass rush shouldn't be too strong.
M.Nabers o63.5 Rec Yds-114
$1.00
Nabers had a strong return in W1, being targeted in 38% of his routes and being Dart's first read in 36.4% of the Giants QBs pass attempts. Combine that with 40% of his team's air yards and MNF should be profitable for him.
Kyle Murray
Kyle Murray
Last 30d: 145-133-7 (+11.8u)
C.Skattebo o12.5 Rush Att-120
1.2u
Tyler Shoemaker
Tyler Shoemaker
Last 30d: 81-105-1 (-17.8u)
NYG +7.5-110
1.1u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 27-93-4 (-3.2u)
Adam Kaufman
Adam Kaufman
Last 30d: 191-209-5 (-29.0u)
NYG +7.5-115
0.57u
Stuck 🚨
Stuck 🚨
Last 30d: 71-71-3 (-0.1u)
LA -7-110
0.45u
Sandy Plashkes
Sandy Plashkes
Last 30d: 100-78-3 (+44.7u)
LA -7-110
1.5u
OldSchool0909
Last 30d: 73-103-2 (-30.3u)
LA -7.5-102
0.98u
Frank Ammirante
Frank Ammirante
Last 30d: 76-71-0 (-4.2u)
NYG +7-105
1.05u
Doug Ziefel
Doug Ziefel
Last 30d: 327-381-9 (+5.6u)
NYG +7.5-120
0.6u
NYG +8.5-115
0.57u
Brandon Kravitz
Brandon Kravitz
Last 30d: 51-60-1 (-3.3u)
NYG +7.5-115
1.15u

Giants vs. Rams Previews & Analysis

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Giants vs. Rams Props

Prop Projections

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Prop Odds Comparison

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Giants vs. Rams Public Betting Percentages

Away Logo

Giants

Public

58%

Bets%

42%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams
2-21-01-12-10-1
Giants
3-13-00-11-02-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams
2-20-12-01-21-0
Giants
2-22-10-10-12-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams
2-2N/AN/A2-10-1
Giants
3-1N/AN/A1-02-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 11thSFL 7-27-3.5 LU 47.5SF -200
Aug 28th@LACW 20-18+3.5 WU 38LA +145
Aug 22ndNOW 34-0+1.5 WU 38.5LA +104
Aug 15th@KCW 20-12+1.5 WU 36.5LA +106
Jan 25th@SEAL 27-31+2.5 LO 45.5SEA +120

Giants vs. Rams Injury Updates

Giants Injuries

  • Braxton Berrios
    WR

    Berrios is out with ankle

    Out

  • Jaxson Dart
    QB

    Dart is out with knee

    Out

Rams Injuries

  • Colby Parkinson
    TE

    Parkinson is questionable with shoulder

    Questionable

  • Ronnie Rivers
    RB

    Rivers is out with calf

    Out

  • Terrance Ferguson
    TE

    Ferguson is out with ankle

    Out

  • Konata Mumpfield
    WR

    Mumpfield is questionable with shoulder

    Questionable

Team Stats
182
Total Yards
481
55
Total Plays
60
3.3
Yards Per Play
8

Passing

131
YDS
327
14/32
Comps/Atts
22/31
3.824
YPA
9.938
0/1
TDs/INTs
4/1
2/1
Sacks/Yards
1/9

Rushing

52
Rush Yards
163
21
Attempts
28
2.476
YPC
5.821
0
TDs
0

Turnovers

0
Fumbles Lost
1
1
Interceptions
1

Efficiency

0/2 0%
Redzone
3/3 100%
3/14 0%
3rd Down
5/9 0%
1/2 0%
4th Down
0/0 0%

First Downs

11
Total
23
8
Pass
15
2
Rush
8
1
Penalty
0
3/20
Penalties/Yards
6/50
27:25
Possession
32:35

Giants vs. Rams Odds Comparison

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Giants at Rams Team Totals

MatchupOverUnder
Giants
3-1
N/A
N/A
Rams
2-2
N/A
N/A