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Titans vs. 49ers Odds & Betting Predictions - December 14, 2025

Titans at 49ers

9:25 pm • FOX

Tennessee Titans

1-9
@

San Francisco 49ers

7-4

Titans at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Titans
1-9
N/A
N/A
N/A
49ers
7-4
N/A
N/A
N/A
location pinSunday 9:25 p.m.
December 14, 2025
Levi's StadiumSanta Clara

Titans vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Titans vs. 49ers Public Betting Percentages

Away Logo

Titans

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 2-3 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 5-2 in their road games against the spread
  • The totals have gone OVER in 3 of 49ers' last 5 games
  • The totals have gone OVER in 2 of 49ers' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		6-51-35-24-22-3
Titans		5-63-32-3N/A5-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		7-42-25-24-23-2
Titans		7-45-12-3N/A7-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		7-4N/AN/A5-12-3
Titans		1-9N/AN/AN/A1-10

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 16th@ARIW 41-22---
Nov 9thLAL 26-42---
Nov 2nd@NYGW 34-24---
Oct 26th@HOUL 15-26---
Oct 20thATLW 20-10---

49ers vs. Titans Injury Updates

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Titans Injuries

  • Calvin Ridley
    WR

    Ridley is out with leg

    Out

  • Bryce Oliver
    WR

    Oliver is out with knee

    Out

  • Kevin Winston
    S

    Winston is doubtful with hamstring

    Doubtful

  • Elic Ayomanor
    WR

    Ayomanor is out with hamstring

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Mac Jones logo
    Mac Jones
    2151
    pyds
  • passing touchdowns
    Mac Jones logo
    Mac Jones
    13
    ptd
  • rushing yards
    Christian McCaffrey logo
    Christian McCaffrey
    707
    ryds
  • rushing touchdowns
    Christian McCaffrey logo
    Christian McCaffrey
    6
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyIsaac GuerendoJordan James
WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
TEGeorge KittleLuke FarrellJake TongesBrayden Willis
LTTrent WilliamsSpencer Burford
LGBen BartchNick Zakelj
CJake BrendelMatt HennessyDrake Nugent
RGDominick PuniConnor Colby
RTColton McKivitzAusten Pleasants
LDENick BosaYetur Gross-MatosRobert BealWilliam Bradley-King
RDEMykel WilliamsBryce HuffSam Okuayinonu
WLBDee WintersNick MartinStone BlantonJalen Graham
MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
LCBRenardo GreenJakob Robinson
SSJi'Ayir BrownMalik MustaphaDerrick Canteen
FSJason PinnockMarques SigleSiran Neal
RCBDeommodore LenoirDarrell Luter
PThomas Morstead
PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
KRIsaac GuerendoJunior Bergen
LSJon Weeks
DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
RWRRicky PearsallJordan WatkinsMalik Turner
NTJordan ElliottC.J. WestKalia Davis
FBKyle Juszczyk
NBUpton StoutChase Lucas
LWRBrandon AiyukMalik Turner
Team Stats

Passing

1636
YDS
2800
194/332
Comps/Atts
268/388
5.886
YPA
7.57
6/6
TDs/INTs
20/10
41/318
Sacks/Yards
19/137

Rushing

789
Rush Yards
1043
200
Attempts
295
3.945
YPC
3.536
3
TDs
8

Turnovers

Fumbles Lost
6
Interceptions
10

Efficiency

8/17 47.06%
Redzone
25/40 62.5%
39/131 0%
3rd Down
63/138 0%
5/14 0%
4th Down
8/15 0%

First Downs

151
Total
240
98
Pass
152
40
Rush
71
13
Penalty
17

Misc

/
Penalties/Yards
/
Possession

Titans vs. 49ers Odds Comparison

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Titans at 49ers Team Totals

MatchupOverUnder
Titans
1-9
N/A
N/A
49ers
7-4
N/A
N/A