NFL Odds, Picks & Predictions For Every Week 2 Game: Your Guide To Betting All 13 Sunday Matchups

NFL Odds & Picks

Week 1 of the NFL season is in the books, now it's time to get your Week 2 bets sorted!

Below you'll find Week 2 NFL odds outlined for every matchup, followed by a betting preview (and pick!) for each.

The mighty NFC West and AFC West are the only divisions sporting 1-0 records across the board after Week 1, while every NFC North team sputtered to an 0-1 start. While some teams look to keep the momentum going, others are hoping for an early bounce back with a long season ahead.

Saints at Panthers Odds

Joe Klein: New Orleans deserves to be favored in this game because of its top-end talent and coaching staff. The Saints were rightly upgraded by the market after their dominant performance against Green Bay and might be a playoff team.

However, the Saints appear to be limping into this game because of key injuries on defense. Keep an eye on Marshon Lattimore's status Sunday after he was listed as questionable, which is grim for New Orleans.

Star tackle Taylor Moton was added to Carolina's injury report on Thursday, but is expected to play. With Moton, the Panthers will be extremely competitive against a banged-up Saints defense, especially up front.

I'm going to back Carolina here. If the injury report breaks in favor of the Panthers, I'd suggest moving the wager up to a full unit. I'd bet this with juice at -115 or better.

Pick: Carolina +3.5 (-110) at BetMGM (0.75 units)

Bengals at Bears Odds

Phillip Kall: Both the Bengals and Bears feature defenses that utilize pressure to protect their lack of talent on the backend. In this matchup, they will each have their chance to wreak havoc as the offensive lines they face struggle.

With both fronts set to create problems, the edge will lie with the offense that can make the one or two pop plays needed to swing momentum. In this case, the team more likely to do so is the Bengals.

Their assortment of talented receivers is a mismatch for Chicago’s young defensive backs. We saw the Bears blow two plays and the Rams instantly make them pay with two touchdowns. Bengals coach Zac Taylor comes from Sean McVay’s coaching tree and should know how to replicate what gave the Bears troubles.

I believe the Bengals can win this outright and start 2-0 for the first time since 2018. However, I still want to take the points to be safe.

Pick: Bengals +2.5 at DraftKings | Down to a pick’em

Texans at Browns Odds

Mike Vitanza: Over the last couple of seasons, we’ve seen first-hand exactly what Nick Chubb is capable of on the ground, particularly in matchups with positive game scripts against subpar opponents. That, my friends, is exactly what we have here in Week 2.

Even after a victory against one of the worst teams in football last week, this Texans defense ranks amongst the worst against the run by nearly all metrics. Coming into the season, the consensus was also that this was one of the worst units in the NFL. This week, they take on one of the league’s strongest rushing attacks in Chubb and Kareem Hunt.

If the current line of -13.5 holds true, we should see a positive game script for Chubb nearly all day. In the past, we’ve seen the Browns lean on him heavily in these types of situations. Last season, in games with at least 19 carries, Chubb averaged 116 yards on the ground. Even with Hunt mixing in, he should eclipse 19 carries in this one given the opponent.

At the current total of 87.5 rushing yards, Chubb will only need to average 4.4 yards per carry if he handles the ball on the ground 20 times. In 2020, he averaged 5.6 yards per attempt on the season. I’m targeting the Chubb over as my main play in this one and would be comfortable playing it up to a total of 95 if the line increases between now and kickoff.

Pick: Nick Chubb Over 87.5 Rushing Yards (-115) at BetMGM

Rams at Colts Odds

Billy Ward: I'm expecting the Rams offense to rule the day this week. Matthew Stafford already seems to have good chemistry with Cooper Kupp and tight end Tyler Higbee, with the latter seeing targets on six of Stafford's 26 throws (23%).

If that share of the work continues to flow his way and Stafford throws five to 10 more passes, Higbee should blow past his receptions prop. I'd bet it this down to -170.

Pick: Tyler Higbee Over 3.5 Receptions (-158) at FanDuel

Broncos at Jaguars Odds

Brandon Anderson: This line has moved in Denver's direction after opening below a field goal before Week 1, but there's still value on the Broncos. Remember how Teddy Bridgewater is 36-14 ATS as a starter? He's even better on the road. Teddy Covers is a surreal 22-3 ATS on the road lifetime, an unbelievable 88% win rate.

You have to really squint to talk yourself into the Jaguars. It's basically a contrarian play and a bet on Trevor Lawrence finding a backdoor cover. I'm not taking that bet, not against this nasty defense.

Denver is a perfect addition to your teaser with this line at six or below, meaning you only need the league's best D to beat up on a shaky offense and take care of business. We'll play them for the cover here, trusting the defense to get the job done. And in the end, we're trusting Bridgewater to do what he does best: Teddy Covers.

Pick: Broncos -5.5 (-118) at FanDuel

Bills at Dolphins Odds

Phillip Kall: If the Bills don’t allow a blocked punt or hit either of their two open deep balls, this game would feel much different. Instead, the Bills have all eyes on them as a road favorite in a game that could leave them two back in the AFC East.

Being behind two games early in the season is far from a place to worry, but could be a blow to Buffalo's overall confidence. With the extra value from this game, I expect Buffalo to come in focused and limit the Week 1 mistakes.

The offense should be in a better position, as Miami will not be able to create pressure with just four pass-rushers. Then, if the Dolphins choose to blitz their corners, they will be left one-on-one situations. This should play into Buffalo’s hands, as it looks to spread the field and attack. Back the Bills to win and continue their division winning streak. I'd play this up to -4.5.

Pick: Bills -3.5 (+105) at PointsBet

Patriots at Jets Odds

Michael Arinze: Last Sunday, I saw this game listed with New England as a 3.5-point favorite. Now, the Patriots are up to a six-point favorite across the board. While that's quite a move to be laying six points on the road with a rookie quarterback, I think there are several factors at play here:

• The Jets will be without a key player on their offensive line in Mekhi Becton.
• New York is also dealing with cluster injuries within their linebacker group.
• The Jets were outgained by almost 130 yards in the box score and lost 19-14 in Week 1.
• The Patriots outgained their opponent by nearly 140 yards and lost 17-16.

Bill Belichick rarely loses outright in Week 1 (14-3 straight up). But in his two earlier losses, he not only bounced back to win in Week 2, but he also won both games by at least 16 points.

However, if you played the Patriots at the current number, you'd be losing a ton of line value. Instead, I'd recommend you use New England as part of a two-team six-point teaser (-110) to bring the line down to a pick 'em. You can pair them with Denver at -6 and play the Broncos down to a pick 'em as well.

Pick: Add Patriots (+6 to pick'em) to two-team, six-point teaser with Broncos at BetMGM

49ers at Eagles Odds

Brandon Anderson: It feels like the misleading final scores in Week 1 are buying us a few points of value in Week 2. The 49ers dominated the only portion of the game that mattered but ended up looking a bit frenzied with their frenetic finish. The Eagles were stout but mostly benefited from a bad Falcons roster imploding, ballooning the final score to a more dominant-looking win than it really was.

The Eagles have a slight advantage in the trenches, but San Francisco is no slouch there. If that's mostly a draw, then we have to look for edges elsewhere. And while Jalen Hurts and DeVonta Smith had nice Week 1 performances for Philly, there's little question that Jimmy Garoppolo, George Kittle, Deebo Samuel and other 49ers are the better offensive weapons by a wide margin, especially in Kyle Shanahan's dangerous system.

I would've expected this line to be near a touchdown before Week 1, with the 49ers contending for the No. 1 seed in the NFC and the Eagles more likely to push for the No. 1 pick. Now that this line has dropped down to just -3, I'm very happy to grab the 49ers. They're the better team with more talent on both sides of the ball and a real coaching advantage.

At -3, I can win by a late field goal and take the push if needed. This line is dropping, so it's tempting to wait for the hook and hope to get to -2.5, but it's just as likely to go back the other way and I don't want to risk losing the hook. I'll grab the 49ers at -3 while it's there and trust San Francisco to get the road win in Week 2.

Pick: 49ers -3 (+105) at PointsBet

Raiders at Steelers Odds

Mike Randle: The Raiders are traveling to the East Coast on a short week to take on the Steelers in a second consecutive physical game. Pittsburgh’s defense tallied three sacks, eight quarterback hits, a fumble recovery and blocked punt touchdown at Buffalo, a much better team than Las Vegas.

The Raiders will be without Josh Jacobs and are coming off a season during which they allowed 29 points per game on the road. The Raiders were lucky to get their home win against Baltimore and don't have the roster talent to keep this game close on a short week.

Under Jon Gruden, Las Vegas has earned some surprising road victories, including at Kansas City last season, but those kinds of performances usually aren't against teams with physical defenses. I'm backing the Steelers to win this game by at least a touchdown over a Las Vegas team that is off an emotional Monday Night Football win and without its top running back. I'd play this to -7.

Pick: Steelers -6 (-110) at BetMGM

Vikings at Cardinals Odds

Brandon Anderson: If you believe in Mike Zimmer, it's hard not to like the Vikings here. Minnesota has been terrific outside of its division under Zimmer and even better after a loss. If you trust the Vikings, you should be grateful for Week 1 overreactions moving this line above a field goal and grab that line while it's there.

I do not trust the Vikings.

This is a team that could have had a great season if everything on paper worked out, but it also felt like things could go the other direction in a hurry. The team was never healthy in preseason, and the entire QB room didn't get time with the team because of COVID protocol. Zimmer and Kirk Cousins were already openly feuding at halftime of Week 1, and you have to wonder if the Vikings still believe in their QB or their coach.

The public is all over the Cardinals, and this is a classic overreaction spot. Most of our team at The Action Network is backing the Vikings. But sometimes the public is right, and I think the Week 1 reactions are spot on in this case. Something is rotten in Minnesota. This feels like a game where everything goes wrong again and all the Monday morning shows are talking about the end of the Cousins and Zimmer era in Minnesota. It doesn't help matters that the Vikings have usually struggled to contain mobile quarterbacks either.

If Kyler Murray has a huge game against this talented defense, he could be the early season MVP favorite. Everyone's on the Cardinals, but I'm fading the faders and sticking with the public. Sometimes the overreaction is exactly right. Minnesota has major struggles on the line and at corner, and that's exactly where Arizona is built to beat them. Take the Cardinals and take the points.

Pick: Cardinals -3.5 (+100) at PointsBet

Falcons at Buccaneers Odds

Michael Arinze: Our odds page shows that the lookahead number for this game had the Buccaneers as an 8.5-point home favorite. That number has now ballooned as high as 12.5 at some sportsbooks after Atlanta's poor showing against the Eagles. But here's some context you should be aware of:

• Brady is 6-0 SU and  5-1 ATS in his career against Atlanta.
• The total has gone over in nine of the last 10 meetings.

When you combine Tom Brady's success against this NFC South opponent with the optimism coming out of the Buccaneers camp from players like Evans, it's hard not to expect points in this game.

But let me pay off the tease in the opening about the other Buccaneers player who is undefeated against the Falcons. The player in question is none other than Antonio Brown.

Not only is he 4-0 against the Falcons, but he has recorded at least 93 receiving yards in all four games. When I checked earlier in the week, I saw some sportsbooks set his yardage prop at 66.5. This prop's been getting hit and is now up to 70.5. However, you can still find a 68.5 available at Unibet.

You'll want to jump on this over before Unibet recognizes they're priced below the market and adjusts.

Pick: Antonio Brown Over 68.5 Receiving Yards (-115) at Unibet

Cowboys at Chargers Odds

Raheem Palmer: Given the Cowboys' injuries and defensive issues, the Chargers have been bet up from -2.5 to -3. I agree with the line movement as L.A. should win this game, but I can't recommend a play on them at that number.

However, I do believe there's some value on the total. If you listened to the Action podcast with me and Brandon Anderson, you’ll know that I suggested the over 51.5 points based on those lookahead lines. Nevertheless, these markets move fast and we’ve already seen movement on this line up to 55 points.

I believe there’s still some value there. Both teams have high-powered offenses that are capable of coming close to hitting this total themselves. Both will also be taking a step down in competition after playing what’s believed to be two of the league's best pass rushes in Week 1.

Despite facing strong defenses in Week 1, both teams performed well. I'm expecting these teams' red-zone percentages to regress to the mean this week and if that's the case, this game should fly over the total. This game is a shootout. Jump on the over before this line gets to 55.

Pick: Over 54.5 (-106) at FanDuel

Titans at Seahawks Odds

Raheem Palmer: Week 2 is always the most profitable week for sportsbooks, as the market always over adjusts based on what we saw last week. I believe this spread is too high, as we've gone from a lookahead line of 4.5 to 6.5. My model makes this game Seahawks -5, so I think there's value on the road team at 6.5.

The Titans have historically performed well after losing by double digits in the Mike Vrabel era. Since 2019, the Titans are 7-0 straight-up following a double-digit loss. Trends aside, the biggest advantage the Titans have is the matchup between their wide receivers in A.J. Brown and Julio Jones against D.J. Reed and Tre Flowers.

If the Titans can protect Ryan Tannehill, I believe they can do enough to keep this game close. Tennessee hasn't found itself catching a number as high as this often with Tannehill as its starter. That tells me this is a huge over adjustment. Take the points with the road team.

Pick: Titans +6.5 (+100) at PointsBet