Patriots vs. Bills Odds & Betting Predictions - October 4, 2026

Patriots at Bills

5:00 pm • CBS
29 - 26

Patriots at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Patriots
3-2
+3
+7-113
o49.5-106
+272
Bills
4-1
u49.5
-7-106
u49.5-111
-350
location pinSunday 5:00 p.m.
October 04, 2026
Highmark StadiumOrchard Park
Patriots vs. Bills Expert Picks
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 52-60-0 (-14.3u)
Under 48.5 (Live)-110
1.1u
From Ringer betting column - never logged
The Degenerates
The Degenerates
Last 30d: 53-52-1 (-2.6u)
BUF -6.5 (Live)-112
1.12u
Collin Whitchurch
Collin Whitchurch
Last 30d: 84-120-3 (-5.0u)
T.Henderson Anytime TD Scorer Yes+274
0.25u
Jeremiah Rose
Jeremiah Rose
Last 30d: 51-56-2 (-5.7u)
BUF -6.5-120
0.3u
Charlie DiSturco
Charlie DiSturco
Last 30d: 99-174-0 (+17.8u)
Over 49.5-105
0.5u
Action Network Live!
Action Network Live!
Last 30d: 25-49-0 (+2.6u)
A.Borregales o5.5 Kicking Pts-118
1u
Vegas Refund
Vegas Refund
Last 30d: 33-36-2 (-7.0u)
BUF -6.5-120
1.2u
Mjaybrod
Mjaybrod
Last 30d: 58-83-1 (-24.5u)
NE o20.5-114
0.88u
💰🦡 Jake
💰🦡 Jake
Last 30d: 66-81-0 (-1.1u)
Under 49.5-110
1.65u
Doug Ziefel
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
J.Cook o1.5 Recs+100
0.5u
R.Doubs o3.5 Recs+140
0.5u
H.Henry u3.5 Recs-120
0.6u
Charlie DiSturco
Charlie DiSturco
Last 30d: 99-174-0 (+17.8u)
K.Shakir o35.5 Rec Yds-111
0.5u
Allan Lem
Allan Lem
Last 30d: 42-31-1 (+0.6u)
D.Kincaid u4.5 Recs-146
0.5u
Tailing @The_Oddsmaker
Collin Whitchurch
Collin Whitchurch
Last 30d: 84-120-3 (-5.0u)
D.Kincaid u4.5 Recs-122
0.5u
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 46-56-0 (-0.8u)
D.Kincaid u4.5 Recs-122
0.5u
This reminds me a bit of the Dalton Schultz under last week. I know Kincaid is a beast, he’s currently top 5 in my fantasy rankings, but he’s much more of a big-play threat this year than a Tyler Warren type who might catch 9 balls for 50 yards. Kincaid could absolutely go 4/90/2 here, which would be great for fantasy and still cash this under. Despite seeing mostly downfield targets, Kincaid has an 82% catch rate, a career high and about 15% above expected, so there’s some regression coming there. He’s also historically been less efficient against man coverage. The Pats may play a little less man with Christian Gonzalez out, but that probably opens things up more for DJ Moore and the other WRs too, which isn’t necessarily helping Kincaid’s target volume. New England hasn’t faced any TEs of Kincaid’s caliber yet, but they’ve generally held the position below expectation. I have him closer to 4.1 receptions with around a 60% chance to stay under 4.5. Again, he can still do a TON of damage on 3-4 catches.
MJC
MJC
Last 30d: 7-9-0 (+3.6u)
J.Cook Anytime TD Scorer Yes-108
1u
Played on NoVig
J.Cook 2+ TDs Yes+470
0.25u
Kyle Murray
Kyle Murray
Last 30d: 150-136-9 (+11.1u)
R.Stevenson o2.5 Recs-114
1u
Frank Ammirante
Frank Ammirante
Last 30d: 92-87-0 (-7.2u)
D.Maye u234.5 Pass Yds-113
1.13u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 33-115-6 (-3.5u)
D.Maye Anytime TD Scorer Yes+500
0.2u
J.Allen 2+ TDs Yes+600
0.17u
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 52-60-0 (-14.3u)
BUF -6.5-115
1.15u
Mike McNamara
Mike McNamara
Last 30d: 69-72-1 (-1.0u)
BUF -7-110
0.4u
Kev Mahserejian
Kev Mahserejian
Last 30d: 14-17-0 (+0.4u)
BUF -6.5-115
1u
Kendra Middleton
Kendra Middleton
Last 30d: 16-25-0 (-1.6u)
Under 48.5-102
0.5u
RoyalsProps
RoyalsProps
Last 30d: 35-35-1 (-5.9u)
D.Kincaid o50.5 Rec Yds-114
1.14u
Frank Ammirante
Frank Ammirante
Last 30d: 92-87-0 (-7.2u)
BUF -6.5-115
1.15u
Doug Ziefel
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
D.Maye u0.5 Int+120
0.42u
Adam Kaufman
Adam Kaufman
Last 30d: 270-284-7 (-31.1u)
NE u10.5 (1H)-170
0.25u
BUF -2.5 (2Q)-115
0.22u
Under 24.5 (1H)-115
0.25u
Sandy Plashkes
Sandy Plashkes
Last 30d: 101-87-3 (+43.0u)
NE +7-120
1.5u
Adam Kaufman
Adam Kaufman
Last 30d: 270-284-7 (-31.1u)
NE +7-115
1u
NE u20.5-113
0.5u
Nick Giffen
Nick Giffen
Last 30d: 52-105-0 (+0.4u)
NE +7-115
0.5u
Doug Ziefel
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
NE +7-115
0.5u

Patriots vs. Bills Previews & Analysis

  • Action Analytics: Data-Driven Picks for Week 4 article feature image

    Action Analytics: Data-Driven Picks for Week 4

    Action Predictive Analytics•
    Oct 4, 2026 UTC
  • Week 4 Luck Rankings Dashboard: All Edges in One Place article feature image

    Week 4 Luck Rankings Dashboard: All Edges in One Place

    Nick Giffen•
    Oct 4, 2026 UTC
  • Koerner's Week 4 Pick'em & Confidence Rankings article feature image

    Koerner's Week 4 Pick'em & Confidence Rankings

    Sean Koerner•
    Oct 4, 2026 UTC
  • Patriots vs. Bills: Mayeday! Mayeday! article feature image

    Patriots vs. Bills: Mayeday! Mayeday!

    Doug Kezirian•
    Oct 4, 2026 UTC
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Patriots vs. Bills Props

Prop Projections

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Patriots vs. Bills Public Betting Percentages

Away Logo

Patriots

Public

34%

Bets%

66%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills
4-12-12-03-11-0
Patriots
4-12-02-12-02-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills
4-12-12-03-11-0
Patriots
2-31-11-21-11-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills
4-1N/AN/A3-11-0
Patriots
3-2N/AN/A2-01-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 27thLACW 24-16-7.5 WU 50.5BUF -350
Sep 18thDETW 41-31-5.5 WO 54.5BUF -250
Sep 13th@HOUW 36-31-1.5 WO 44.5BUF -118
Aug 27thPITW 28-27-1.5 LO 36.5BUF -141
Aug 22nd@CLEW 31-7+2.5 WO 36.5BUF +124

Bills vs. Patriots Injury Updates

Bills Injuries

  • D.J. Moore
    WR

    Moore is questionable with shoulder

    Questionable

  • Joshua Palmer
    WR

    Palmer is questionable with shoulder

    Questionable

Patriots Injuries

  • Mack Hollins
    WR

    Hollins is out with calf

    Out

  • A.J. Brown
    WR

    Brown is out with ankle

    Out

  • TreVeyon Henderson
    RB

    Henderson is out with ankle

    Out

Team Stats
405
Total Yards
340
73
Total Plays
54
5.5
Yards Per Play
6.3
269
YDS
253
22/37
Comps/Atts
23/33
6.895
YPA
7.324
3/1
TDs/INTs
1/1
1/7
Sacks/Yards
1/4
143
Rush Yards
91
35
Attempts
20
4.086
YPC
4.55
1
TDs
2

Turnovers

1
Fumbles Lost
1
1
Interceptions
1

Efficiency

3/3 100%
Redzone
2/4 50%
5/12 0%
3rd Down
6/12 0%
2/2 0%
4th Down
1/1 0%

First Downs

26
Total
19
15
Pass
9
10
Rush
6
1
Penalty
4
6/35
Penalties/Yards
5/31
33:41
Possession
26:19

Patriots vs. Bills Odds Comparison

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Patriots at Bills Team Totals

MatchupOverUnder
Patriots
3-2
N/A
N/A
Bills
4-1
N/A
N/A