Patriots vs. Bills Odds & Betting Predictions - October 4, 2026
Patriots at Bills
5:00 pm • CBSPatriots at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Patriots 3-2 | +3 | +7-113 | o49.5-106 | +272 |
Bills 4-1 | u49.5 | -7-106 | u49.5-111 | -350 |

Highmark StadiumOrchard Park
Patriots vs. Bills Expert Picks
Anthony Dabbundo
Last 30d: 52-60-0 (-14.3u)
Under 48.5 (Live)-110
1.1u
From Ringer betting column - never logged
The Degenerates
Last 30d: 53-52-1 (-2.6u)
BUF -6.5 (Live)-112
1.12u
Collin Whitchurch
Last 30d: 84-120-3 (-5.0u)
T.Henderson Anytime TD Scorer Yes+274
0.25u
Jeremiah Rose
Last 30d: 51-56-2 (-5.7u)
BUF -6.5-120
0.3u
Charlie DiSturco
Last 30d: 99-174-0 (+17.8u)
Over 49.5-105
0.5u
Action Network Live!
Last 30d: 25-49-0 (+2.6u)
A.Borregales o5.5 Kicking Pts-118
1u
Vegas Refund
Last 30d: 33-36-2 (-7.0u)
BUF -6.5-120
1.2u
Mjaybrod
Last 30d: 58-83-1 (-24.5u)
NE o20.5-114
0.88u
💰🦡 Jake
Last 30d: 66-81-0 (-1.1u)
Under 49.5-110
1.65u
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
J.Cook o1.5 Recs+100
0.5u
R.Doubs o3.5 Recs+140
0.5u
H.Henry u3.5 Recs-120
0.6u
Charlie DiSturco
Last 30d: 99-174-0 (+17.8u)
K.Shakir o35.5 Rec Yds-111
0.5u
Allan Lem
Last 30d: 42-31-1 (+0.6u)
D.Kincaid u4.5 Recs-146
0.5u
Tailing @The_Oddsmaker
Collin Whitchurch
Last 30d: 84-120-3 (-5.0u)
D.Kincaid u4.5 Recs-122
0.5u
Sean Koerner🔮
Last 30d: 46-56-0 (-0.8u)
D.Kincaid u4.5 Recs-122
0.5u
This reminds me a bit of the Dalton Schultz under last week. I know Kincaid is a beast, he’s currently top 5 in my fantasy rankings, but he’s much more of a big-play threat this year than a Tyler Warren type who might catch 9 balls for 50 yards. Kincaid could absolutely go 4/90/2 here, which would be great for fantasy and still cash this under.
Despite seeing mostly downfield targets, Kincaid has an 82% catch rate, a career high and about 15% above expected, so there’s some regression coming there. He’s also historically been less efficient against man coverage. The Pats may play a little less man with Christian Gonzalez out, but that probably opens things up more for DJ Moore and the other WRs too, which isn’t necessarily helping Kincaid’s target volume.
New England hasn’t faced any TEs of Kincaid’s caliber yet, but they’ve generally held the position below expectation. I have him closer to 4.1 receptions with around a 60% chance to stay under 4.5. Again, he can still do a TON of damage on 3-4 catches.
MJC
Last 30d: 7-9-0 (+3.6u)
J.Cook Anytime TD Scorer Yes-108
1u
Played on NoVig
J.Cook 2+ TDs Yes+470
0.25u
Kyle Murray
Last 30d: 150-136-9 (+11.1u)
R.Stevenson o2.5 Recs-114
1u
Frank Ammirante
Last 30d: 92-87-0 (-7.2u)
D.Maye u234.5 Pass Yds-113
1.13u
TAN Pod Touchdown Show
Last 30d: 33-115-6 (-3.5u)
D.Maye Anytime TD Scorer Yes+500
0.2u
J.Allen 2+ TDs Yes+600
0.17u
Anthony Dabbundo
Last 30d: 52-60-0 (-14.3u)
BUF -6.5-115
1.15u
Mike McNamara
Last 30d: 69-72-1 (-1.0u)
BUF -7-110
0.4u
Kev Mahserejian
Last 30d: 14-17-0 (+0.4u)
BUF -6.5-115
1u
Kendra Middleton
Last 30d: 16-25-0 (-1.6u)
Under 48.5-102
0.5u
RoyalsProps
Last 30d: 35-35-1 (-5.9u)
D.Kincaid o50.5 Rec Yds-114
1.14u
Frank Ammirante
Last 30d: 92-87-0 (-7.2u)
BUF -6.5-115
1.15u
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
D.Maye u0.5 Int+120
0.42u
Adam Kaufman
Last 30d: 270-284-7 (-31.1u)
NE u10.5 (1H)-170
0.25u
BUF -2.5 (2Q)-115
0.22u
Under 24.5 (1H)-115
0.25u
Sandy Plashkes
Last 30d: 101-87-3 (+43.0u)
NE +7-120
1.5u
Adam Kaufman
Last 30d: 270-284-7 (-31.1u)
NE +7-115
1u
NE u20.5-113
0.5u
Nick Giffen
Last 30d: 52-105-0 (+0.4u)
NE +7-115
0.5u
Doug Ziefel
Last 30d: 362-405-7 (+11.4u)
NE +7-115
0.5u
Patriots vs. Bills Previews & Analysis
Patriots vs. Bills Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Patriots vs. Bills Public Betting Percentages
Betting Trends
- Bills are 4-1 in their last 5 games.
- Bills are 4-1 in their last 5 games against the spread
- Bills are 2-0 in their road games against the spread
- The totals have gone OVER in 4 of Bills' last 5 games
- The totals have gone OVER in 2 of Bills' 3 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Bills vs. Patriots Injury Updates

Bills Injuries
- D.J. MooreWR
Moore is questionable with shoulder
Questionable
- Joshua PalmerWR
Palmer is questionable with shoulder
Questionable

Patriots Injuries
- Mack HollinsWR
Hollins is out with calf
Out
- A.J. BrownWR
Brown is out with ankle
Out
- TreVeyon HendersonRB
Henderson is out with ankle
Out
Team Stats
Patriots vs. Bills Odds Comparison
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Patriots at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Patriots 3-2 | N/A | N/A |
Bills 4-1 | N/A | N/A |




