Turn your sports knowledge into winning predictions
21+ or 18+ in Certain Locations. 19+ in ON. Please Play Responsibly. Gambling Problem? Call 1-800-GAMBLER. Visit connexontario.ca or Call 1-866-531-2600 in ON.
No Code Needed

49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025

49ers at Seahawks

8:05 pm • FOX
Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

0-0
@

Seattle Seahawks

0-0

49ers at Seahawks Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
0-0
-1.5
-2.5-110
o43.5-105
-135
Seahawks
0-0
u45.5
+2.5-110
u43.5-115
+115
location pinSunday 8:05 p.m.
September 07, 2025
Lumen FieldSeattle
thermometer image70°Fahrenheit
rain image0%Rain
wind image5Wind
49ers vs. Seahawks Expert Picks
Royals Props
Royals Props
Last 30d: 3-6-0 (-4.1u)
G.Kittle o60.5 Rec Yds-125
1.25u
Fanatics
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 106-110-5 (-10.1u)
SEA +1.5-105
1.05u
Early season divisional underdogs Overall: 130-66-6,66% (ROI:27%)

49ers vs. Seahawks Previews & Analysis

  • NFL Week 1 Strategy for Survivor & Pick'em Pools article feature image

    NFL Week 1 Strategy for Survivor & Pick'em Pools

    PoolGenius•
    Sep 1, 2025 UTC
  • NFL Week 1 Betting Trends, Stats, Notes article feature image

    NFL Week 1 Betting Trends, Stats, Notes

    Evan Abrams•
    Sep 1, 2025 UTC
  • NFL Schedule Release Betting Primer: Notes, Stats and Trends for 2025 Season article feature image

    NFL Schedule Release Betting Primer: Notes, Stats and Trends for 2025 Season

    Evan Abrams•
    May 15, 2025 UTC
See more NFL Coverage Right Arrow

49ers vs. Seahawks Props

Prop Projections

See All
Right Arrow

There are no prop projections found for the selected slate. Please check back later.

Prop Odds Comparison

Right Arrow
Right Arrow

No props found

Line Movement Tracker

Right Arrow
Right Arrow

49ers vs. Seahawks Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Seahawks

57%

Bets%

43%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Seahawks		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 23rd@GBL 7-20+3 LU 37.5GB +140
Aug 16thKCW 33-16-5 WO 38SEA -220
Aug 8thLVW 23-23+5.5 WO 36.5LV +200
Jan 5th@LAW 30-25-7.5 LO 38.5SEA -350
Dec 27th@CHIW 6-3-4.5 LU 42.5SEA -225

49ers vs. Seahawks Injury Updates

49ers Injuries

  • Trevis Gipson
    LB

    Gipson is out with ankle

    Out

Seahawks Injuries

    See more NFL Injuries Right Arrow
    Player Stats
    • passing yards
      player logo
      -
      4320
      pyds
    • passing touchdowns
      player logo
      -
      21
      ptd
    • rushing yards
      Kenneth Walker logo
      Kenneth Walker
      573
      ryds
    • rushing touchdowns
      Zach Charbonnet logo
      Zach Charbonnet
      8
      rtd
    Depth Charts
    Right Arrow
    Starter2ND3RD4TH
    QBSam DarnoldDrew LockJalen Milroe
    RBKenneth WalkerZach CharbonnetGeorge HolaniDamien MartinezJacardia Wright
    WRCooper KuppDareke Young
    TEAJ BarnerElijah ArroyoEric SaubertNick Kallerup
    LTCharles CrossAmari Kight
    LGGrey ZabelBryce CabeldueSataoa Laumea
    COlu OluwatimiJalen SundellFederico Maranges
    RGAnthony BradfordChristian HaynesMason Richman
    RTAbraham LucasJosh Jones
    LDEDeMarcus LawrenceDerick HallJared IveyConnor O'Toole
    RDELeonard WilliamsMike MorrisJ.R. Singleton
    WLBTyrice KnightPatrick O'ConnellJamie Sheriff
    MLBErnest JonesDrake Thomas
    LCBJosh JobeNehemiah PritchettShemar Jean-Charles
    SSJulian LoveNick EmmanworiJerrick Reed
    FSCoby BryantD'Anthony BellTy Okada
    RCBRiq WoolenShaquill Griffin
    PMichael Dickson
    HMichael Dickson
    PRTory Horton
    KRTory HortonZach Charbonnet
    LSChris Stoll
    DTJarran ReedRylie Mills
    RWRTory HortonRicky White
    KJason Myers
    LOLBUchenna NwosuBoye Mafe
    LWRJaxon Smith-NjigbaJake BoboCody WhiteTyrone Broden
    FBRobbie OuztsBrady Russell
    NTByron MurphyJohnathan HankinsBrandon PiliQuinton Bohanna
    NBDevon Witherspoon
    ROLBJamie SheriffConnor O'Toole

    49ers vs. Seahawks Odds Comparison

    Right Arrow

    Could not load odds

    See more NFL Odds Right Arrow

    49ers at Seahawks Team Totals

    MatchupOverUnder
    49ers
    0-0
    N/A
    N/A
    Seahawks
    0-0
    N/A
    N/A