Jaguars vs. 49ers Odds & Betting Predictions - September 28, 2025

Jaguars at 49ers

8:05 pm • FOX
26 - 21

Jaguars at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Jaguars
3-1
+5.5
+3.5-119
o45.5-118
+144
49ers
3-1
u48.5
-3.5+104
u45.5-108
-172
location pinSunday 8:05 p.m.
September 28, 2025
Levi's StadiumSanta Clara
Jaguars vs. 49ers Expert Picks
Mjaybrod
Mjaybrod
Last 30d: 68-85-3 (-11.6u)
SF +4.5 (Live)-110
1u
Over 44.5 (Live)-106
0.94u
Jeremiah Rose
Jeremiah Rose
Last 30d: 34-40-1 (-2.7u)
JAC +3.5-129
0.23u
Wags Wins
Wags Wins
Last 30d: 164-146-1 (+12.9u)
Over 45.5-105
1.43u
Brandon Kravitz
Brandon Kravitz
Last 30d: 43-52-0 (-6.6u)
SF -3.5+116
0.5u
Gilles Gallant
Gilles Gallant
Last 30d: 22-65-0 (-6.5u)
B.Thomas Anytime TD Scorer Yes+185
0.55u
Capper Central
Capper Central
Last 30d: 101-54-1 (+33.6u)
Over 45.5-110
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 53-51-0 (-1.6u)
SF -117
1u
Profit boost play
Vegas Refund
Vegas Refund
Last 30d: 38-37-2 (-2.8u)
JAC +3.5-115
1u
Sean Koerner
Sean Koerner
Last 30d: 29-39-0 (-4.1u)
D.Lenoir u4.5 Tackles + Ast+120
0.5u
Lenoir hasn’t cleared this number yet this season, and after doing some digging, it’s pretty clear why. He’s far less involved in run support: a tackle on 4.1% of run plays so far, compared to 9% last year. He’s been lined up in the box/slot only 15% of the time this year (about 80% last season), and he’s at 84% outside corner now. That outside role simply does not provide him with as many tackle chances on run plays, so I am not banking on meaningful positive regression while this usage holds. Accounting for the new role, I have him closer to 4.3 with around 58% to stay under 4.5. Getting plus money here is a nice bonus.
Nick Giffen
Nick Giffen
Last 30d: 47-119-1 (+10.5u)
B. Thomas over 7.5 1st Quarter Rec Yds-117
1u
Brian Thomas Jr. over 7.5 1st Quarter receiving yards (-117 at DK) JAX likely to start with the ball JAX has won the coin toss 3 times this year, and in two of those game they chose to receive the kickoff SF has won the coin toss 3 times this year and chose to defer all three which is standard for Kyle Shanahan who hasn't chosen to receive the ball as far back as my coin toss data goes Has cleared this in 2 of 3 games this year, including in the the game JAX got the ball second, catching one of two targets for 9 yards. Now faces a SF defense that has allowed a higher catch percentage, and catch percentage over expectation (CPOE) than the other three teams the Jaguars have faced this year. We should also expect BTJ's catch rate to improve from the paltry 28% he's had so far, closer to the mid 60% rate he had last year while having a similar aDOT so far this year to his rookie season. The Jaguars have also reportedly made it a point to get BTJ plenty of looks in practice this week to build back that confidence after some ugly drops, which tends not to be a sticky statistic. His receiving yard total is around 57.5 to 58.5 yards across the market, so 7.5 yards represents just 12.9% of that for 25% of game time, of which the Jaguars should have even more than 25% of their total possession by likely starting with the ball. 24% of BTJ's targets have come in the first quarter so far this year, which would equate to around 14 yards if that was also the percentage of yards he accumulated. Only DK has this prop right now, but when other books start to post it, I'd play it up to 9.5 at -110 or 10.5 at even money or better
CeeJ Sports
CeeJ Sports
Last 30d: 8-6-0 (+0.8u)
C.McCaffrey o40.5 Rec Yds-120
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 69-105-3 (-20.3u)
B.Thomas o59.5 Rec Yds-112
1.12u
Picks Office
Picks Office
Last 30d: 63-88-4 (-21.7u)
Over 46.5-115
0.87u
The Favorites Podcast
The Favorites Podcast
Last 30d: 13-13-0 (+0.0u)
JAC +3-105
1u
Boomer Betz
Boomer Betz
Last 30d: 130-100-2 (+44.2u)
C.McCaffrey u46.5 Rec Yds-113
1u
T.Etienne u53.5 Rush Yds-115
1u
B.Thomas o58.5 Rec Yds-109
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 44-97-0 (-19.8u)
JAC +3.5-118
0.85u
@sundaysixpack @ChrisRaybon 2 https://myaction.app/JNv2zeOUXWb
Sunday Six Pack
Sunday Six Pack
Last 30d: 14-10-0 (+2.8u)
JAC +3.5-118
1u
Chris Raybon
Chris Raybon
Last 30d: 23-24-1 (+12.0u)
JAC +3.5-118
0.85u
#SundaySixPack
Mjaybrod
Mjaybrod
Last 30d: 68-85-3 (-11.6u)
Over 47-107
1u
Spicy lemon pepper wings
Stuck 🚨
Stuck 🚨
Last 30d: 47-53-1 (-0.4u)
JAC +3.5-105
0.48u
Grabbed the hook with all of the SF injury uncertainty
💰🦡 Jake
💰🦡 Jake
Last 30d: 102-118-7 (+35.7u)
JAC +3.5-115
1u
Kenny Ducey
Kenny Ducey
Last 30d: 28-22-2 (+4.6u)
Under 47-110
1.1u
Brandon Kravitz
Brandon Kravitz
Last 30d: 43-52-0 (-6.6u)
SF -3.5-105
1.05u
Here’s to hoping Purdy gives it a go 🤞
FTN Fantasy
FTN Fantasy
Last 30d: 79-91-1 (-20.0u)
SF -3.5-110
1u
Brandon Anderson
Brandon Anderson
Last 30d: 29-102-0 (-23.0u)
SF -3-110
1.5u
WEEK 4 LOOKAHEAD : It feels like good vibes in Jacksonville, but that could shift if the Jaguars drop to 1-2 with a loss to the Texans, especially if we start to see more cracks between Liam Coen, Trevor Lawrence, and Brian Thomas Jr., with Lawrence performing so erratically. Jacksonville's offensive line has outperformed expectations but has a much tougher test against that Houston defensive front, and that will continue with Nick Bosa and rookie Mykel Williams waiting next week in San Francisco. The 49ers could be 3-0 by then — and more importantly, it looks like they should have Brock Purdy back in the field. Purdy is practicing and could even play in Week 3, so it would be a surprise to see him sit Week 4 at this point, and I don't think this line has readjusted. I make this San Francisco -5 even with Mac Jones in the lineup, so it jumps to over a touchdown with Purdy. Miss me with your Mac Jones is just as good as Purdy is take. Jones won last week but currently ranks 20th or worse among starting QBs in ADOT and CPOE and 31st in pressure-to-sack rate. Give Purdy some credit for his growth — he doesn't take many sacks and has an ability to create plays that Jones has never had. It's a gift getting this line right at -3, the key number. Don't wait around and miss it next week.
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 44-97-0 (-19.8u)
SF -3-105
1u
Week 4 Lookahead @wheatonbrando https://myaction.app/mwsC0lYENWb

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Jaguars vs. 49ers Props

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Jaguars vs. 49ers Public Betting Percentages

Away Logo

Jaguars

Public

65%

Bets%

35%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers
2-20-22-02-2N/A
Jaguars
3-12-01-12-01-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers
2-21-11-12-2N/A
Jaguars
2-20-22-00-22-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers
3-1N/AN/A3-1N/A
Jaguars
3-1N/AN/A2-01-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 21stARIW 16-15-1.5 LU 44.5SF -125
Sep 14th@NOW 26-21-3 WO 40.5SF -160
Sep 7th@SEAW 17-13-2.5 WU 43.5SF -132
Aug 24thLACW 30-23+2.5 WO 35.5SF +125
Aug 16th@LVW 22-19+4.5 WO 40.5SF +180

49ers vs. Jaguars Injury Updates

49ers Injuries

  • George Kittle
    TE

    Kittle is out with hamstring

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jauan Jennings
    WR

    Jennings is questionable with ankle

    Questionable

  • Brock Purdy
    QB

    Purdy is questionable with toe

    Questionable

  • Ricky Pearsall
    WR

    Pearsall is questionable with knee

    Questionable

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan Watkins
    WR

    Watkins is doubtful with ankle

    Doubtful

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Jaguars Injuries

  • Dyami Brown
    WR

    Brown is questionable with shoulder

    Questionable

  • Cole Van Lanen
    OL

    Van Lanen is questionable with shoulder

    Questionable

  • Montaric Brown
    CB

    Brown is out with ankle

    Out

  • Wyatt Milum
    OL

    Milum is out with knee

    Out

Team Stats
325
Total Yards
389
63
Total Plays
63
5.2
Yards Per Play
6.2
174
YDS
309
21/31
Comps/Atts
22/38
5.613
YPA
7.846
1/0
TDs/INTs
2/2
0/0
Sacks/Yards
1/3
151
Rush Yards
83
32
Attempts
24
4.719
YPC
3.458
1
TDs
0

Turnovers

0
Fumbles Lost
2
0
Interceptions
2

Efficiency

1/2 50%
Redzone
1/3 33.33%
4/14 0%
3rd Down
8/13 0%
1/1 0%
4th Down
0/1 0%

First Downs

18
Total
22
8
Pass
17
8
Rush
3
2
Penalty
2
12/90
Penalties/Yards
5/54
32:31
Possession
27:29

Jaguars vs. 49ers Odds Comparison

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Jaguars at 49ers Team Totals

MatchupOverUnder
Jaguars
3-1
o21-116
u21-106
49ers
3-1
o24.5-103
u24.5-120