Jaguars vs. 49ers Odds & Betting Predictions - September 28, 2025
Jaguars at 49ers
8:05 pm • FOXJaguars at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Jaguars 3-1 | +5.5 | +3.5-119 | o45.5-118 | +144 |
![]() 49ers 3-1 | u48.5 | -3.5+104 | u45.5-108 | -172 |

Levi's StadiumSanta Clara
Jaguars vs. 49ers Expert Picks

Mjaybrod
Last 30d: 68-85-3 (-11.6u)
SF +4.5 (Live)-110
1u
Over 44.5 (Live)-106
0.94u

Jeremiah Rose
Last 30d: 34-40-1 (-2.7u)
JAC +3.5-129
0.23u

Wags Wins
Last 30d: 164-146-1 (+12.9u)
Over 45.5-105
1.43u

Brandon Kravitz
Last 30d: 43-52-0 (-6.6u)
SF -3.5+116
0.5u
Gilles Gallant
Last 30d: 22-65-0 (-6.5u)
B.Thomas Anytime TD Scorer Yes+185
0.55u

Capper Central
Last 30d: 101-54-1 (+33.6u)
Over 45.5-110
1u

Austin Pendergrass
Last 30d: 53-51-0 (-1.6u)
SF -117
1u
Profit boost play

Vegas Refund
Last 30d: 38-37-2 (-2.8u)
JAC +3.5-115
1u

Sean Koerner
Last 30d: 29-39-0 (-4.1u)
D.Lenoir u4.5 Tackles + Ast+120
0.5u
Lenoir hasn’t cleared this number yet this season, and after doing some digging, it’s pretty clear why. He’s far less involved in run support: a tackle on 4.1% of run plays so far, compared to 9% last year. He’s been lined up in the box/slot only 15% of the time this year (about 80% last season), and he’s at 84% outside corner now. That outside role simply does not provide him with as many tackle chances on run plays, so I am not banking on meaningful positive regression while this usage holds.
Accounting for the new role, I have him closer to 4.3 with around 58% to stay under 4.5. Getting plus money here is a nice bonus.

Nick Giffen
Last 30d: 47-119-1 (+10.5u)
B. Thomas over 7.5 1st Quarter Rec Yds-117
1u
Brian Thomas Jr. over 7.5 1st Quarter receiving yards (-117 at DK)
JAX likely to start with the ball
JAX has won the coin toss 3 times this year, and in two of those game they chose to receive the kickoff
SF has won the coin toss 3 times this year and chose to defer all three which is standard for Kyle Shanahan who hasn't chosen to receive the ball as far back as my coin toss data goes
Has cleared this in 2 of 3 games this year, including in the the game JAX got the ball second, catching one of two targets for 9 yards.
Now faces a SF defense that has allowed a higher catch percentage, and catch percentage over expectation (CPOE) than the other three teams the Jaguars have faced this year.
We should also expect BTJ's catch rate to improve from the paltry 28% he's had so far, closer to the mid 60% rate he had last year while having a similar aDOT so far this year to his rookie season.
The Jaguars have also reportedly made it a point to get BTJ plenty of looks in practice this week to build back that confidence after some ugly drops, which tends not to be a sticky statistic.
His receiving yard total is around 57.5 to 58.5 yards across the market, so 7.5 yards represents just 12.9% of that for 25% of game time, of which the Jaguars should have even more than 25% of their total possession by likely starting with the ball.
24% of BTJ's targets have come in the first quarter so far this year, which would equate to around 14 yards if that was also the percentage of yards he accumulated.
Only DK has this prop right now, but when other books start to post it, I'd play it up to 9.5 at -110 or 10.5 at even money or better

CeeJ Sports
Last 30d: 8-6-0 (+0.8u)
C.McCaffrey o40.5 Rec Yds-120
1u

Sandy Plashkes
Last 30d: 69-105-3 (-20.3u)
B.Thomas o59.5 Rec Yds-112
1.12u

Picks Office
Last 30d: 63-88-4 (-21.7u)
Over 46.5-115
0.87u

The Favorites Podcast
Last 30d: 13-13-0 (+0.0u)
JAC +3-105
1u
@Stuckey2 https://myaction.app/FqsJZ7B4YWb

Boomer Betz
Last 30d: 130-100-2 (+44.2u)
C.McCaffrey u46.5 Rec Yds-113
1u
T.Etienne u53.5 Rush Yds-115
1u
B.Thomas o58.5 Rec Yds-109
1u

Action Pod NFL Picks
Last 30d: 44-97-0 (-19.8u)
JAC +3.5-118
0.85u
@sundaysixpack @ChrisRaybon 2 https://myaction.app/JNv2zeOUXWb

Sunday Six Pack
Last 30d: 14-10-0 (+2.8u)
JAC +3.5-118
1u
@ChrisRaybon 2 https://myaction.app/kzy8ZyeUXWb

Chris Raybon
Last 30d: 23-24-1 (+12.0u)
JAC +3.5-118
0.85u
#SundaySixPack

Mjaybrod
Last 30d: 68-85-3 (-11.6u)
Over 47-107
1u
Spicy lemon pepper wings

Stuck 🚨
Last 30d: 47-53-1 (-0.4u)
JAC +3.5-105
0.48u
Grabbed the hook with all of the SF injury uncertainty

💰🦡 Jake
Last 30d: 102-118-7 (+35.7u)
JAC +3.5-115
1u

Kenny Ducey
Last 30d: 28-22-2 (+4.6u)
Under 47-110
1.1u

Brandon Kravitz
Last 30d: 43-52-0 (-6.6u)
SF -3.5-105
1.05u
Here’s to hoping Purdy gives it a go 🤞

FTN Fantasy
Last 30d: 79-91-1 (-20.0u)
SF -3.5-110
1u

Brandon Anderson
Last 30d: 29-102-0 (-23.0u)
SF -3-110
1.5u
WEEK 4 LOOKAHEAD : It feels like good vibes in Jacksonville, but that could shift if the Jaguars drop to 1-2 with a loss to the Texans, especially if we start to see more cracks between Liam Coen, Trevor Lawrence, and Brian Thomas Jr., with Lawrence performing so erratically.
Jacksonville's offensive line has outperformed expectations but has a much tougher test against that Houston defensive front, and that will continue with Nick Bosa and rookie Mykel Williams waiting next week in San Francisco.
The 49ers could be 3-0 by then — and more importantly, it looks like they should have Brock Purdy back in the field.
Purdy is practicing and could even play in Week 3, so it would be a surprise to see him sit Week 4 at this point, and I don't think this line has readjusted. I make this San Francisco -5 even with Mac Jones in the lineup, so it jumps to over a touchdown with Purdy.
Miss me with your Mac Jones is just as good as Purdy is take. Jones won last week but currently ranks 20th or worse among starting QBs in ADOT and CPOE and 31st in pressure-to-sack rate. Give Purdy some credit for his growth — he doesn't take many sacks and has an ability to create plays that Jones has never had.
It's a gift getting this line right at -3, the key number. Don't wait around and miss it next week.

Action Pod NFL Picks
Last 30d: 44-97-0 (-19.8u)
SF -3-105
1u
Week 4 Lookahead @wheatonbrando https://myaction.app/mwsC0lYENWb
Jaguars vs. 49ers Previews & Analysis
Jaguars vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Jaguars vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 3-1 in their last 5 games.
- 49ers are 2-2 in their last 5 games against the spread
- 49ers are 2-0 in their road games against the spread
- The totals have gone OVER in 2 of 49ers' last 4 games
- The totals have gone OVER in 1 of 49ers' 2 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Jaguars Injury Updates

49ers Injuries
- George KittleTE
Kittle is out with hamstring
Out
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jauan JenningsWR
Jennings is questionable with ankle
Questionable
- Brock PurdyQB
Purdy is questionable with toe
Questionable
- Ricky PearsallWR
Pearsall is questionable with knee
Questionable
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan WatkinsWR
Watkins is doubtful with ankle
Doubtful
- Jordan JamesRB
James is doubtful with finger
Doubtful

Jaguars Injuries
- Dyami BrownWR
Brown is questionable with shoulder
Questionable
- Cole Van LanenOL
Van Lanen is questionable with shoulder
Questionable
- Montaric BrownCB
Brown is out with ankle
Out
- Wyatt MilumOL
Milum is out with knee
Out
Team Stats
Jaguars vs. 49ers Odds Comparison
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Jaguars at 49ers Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Jaguars 3-1 | o21-116 | u21-106 |
![]() 49ers 3-1 | o24.5-103 | u24.5-120 |