NFL Betting Picks: 6 Spreads & Totals to Bet For Week 6

Two home underdogs. Two home favorites. And an over.

Our staff breaks down their favorite picks for Week 6 of the 2020 NFL season, featuring spread and total angles for Sunday's main slate.

NFL Picks & Predictions

Click on a pick to skip ahead to that analysis.

Chris Raybon: Steelers -3 vs. Browns

Kickoff: 1 p.m. ET on Sunday | More Game Info

Baker Mayfield (chest), Odell Beckham Jr. (illness) and Jarvis Landry (ribs) all missed or were limited at practice this week, which is not ideal for Mayfield against a Steelers defense that ranks No. 1 in Pressure Rate (41.2%, per Pro Football Reference). Mayfield’s passer rating under pressure this season is 30.9, which ranks 33rd of 34 qualified passers, according to Pro Football Focus,

Making matters worse for Cleveland, guard Wyatt Teller (calf) has been ruled out. With a PFF grade of 94.4 this season, Teller was the No. 1 overall guard in football, and his 94.4 pass-blocking grade also ranked No. 1.

Pittsburgh rates ninth in overall DVOA while Cleveland clocks in at No. 17. The Steelers also have home-field advantage and the better injury situation heading into this game, which should enable them to cover the short spread. I make this game Pittsburgh -5 and like the Steelers up to -4.

Travis Reed: Browns-Steelers Over 51

Kickoff: 1 p.m. ET | More Game Info

An AFC North matchup that has the nostalgic feelings of a defensive battle, but that's not what I'm expecting in this game.

After getting blown out by the Ravens in Week 1, the Browns have turned around their season and are now 4-1. In those four wins, they've averaged a staggering 37.5 points per game on offense. Many of those points were needed as they gave up 28 points per game in those same four wins.

On the Steelers side, Chase Claypool may cover the over by himself. I’m joking, of course, but their offense has scored at least 26 points in all four of their games thus far regardless of who is playing at wide receiver for Pittsburgh.

Neither team is slowly plodding up the field when they get into the end zone, either. Both teams rank in the top half in pace, meaning not only are they scoring, but they are doing it quicker than most.

You can’t just take the number of points scored and add them up to get a projected total, so I turned to my simulations which do the math for me. The average result was the Steelers winning 31-25, which is well over the current total of 51 (compare real-time odds here). Because of that, I would have no problem betting the over up to 52.5 points.

Raheem Palmer: Texans +3.5 at Titans

Kickoff: 1 p.m. ET | More Game Info

If the Tennessee Titans were a stock, this would be the optimal time to sell.

The Titans are coming off a 42-16 upset win over the Bills in which Tennessee benefited from three turnovers, scoring touchdowns on drives starting at the Buffalo 16, 12 and 26.

The Bills' injuries came back to bite them as the absences of Tre’Davious White and Levi Wallace allowed Titans wide receiver A.J. Brown to roam free with impunity, catching seven receptions for 82 yards and a touchdown. And the absence of WR John Brown also meant a dropped pass by Andre Roberts on the opening possession of the game turned into an interception.

With the Bills behind the eight ball from the opening drive, Josh Allen melted down and the game snowballed into a place where the Titans gained control and never relinquished it. Tennessee played as close to a perfect game as you could possibly play, going six-for-six in the red zone.

The market believed that the Titans were dead in the water after sitting out nearly two weeks due to a COVID-19 outbreak, however, this is a worse spot as they host their divisional rivals in the Texans just five days after Tuesday night’s win over the Bills.

After firing their head coach in Bill O’Brien, the Texans have a spark under interim head coach Romeo Crennel and a win here means a lot more for them than the Titans as this is potentially Houston's season as the Texans sit with a 1-4 record. I’m not particularly a fan of handicapping motivation because obviously both teams want to win, but it’s worth noting that given the tendency for teams to end up in let down situations.

That said, the Texans have some key advantages coming into this matchup — most notably, their offense against the Titans defense.

Tennessee defensive lineman DaQuan Jones is questionable to play after sitting out of practice this week. The Titans are already 31st in rushing defense, allowing 5.5 yards per carry and ranking dead-last in explosive run rate with 20% of runs going for 20 or more  yards. This could be a potential breakout game for David Johnson on the ground, making things easier for Deshaun Watson to move the ball through the air, where the Titans haven’t fared any better than their rushing defense.

They're allowing 6.7 yards per pass and are 24th in passing success rate defense. The Texans trio of receivers in Will Fuller, Brandin Cooks and Kenny Stills presents a challenge for a secondary missing No. 1 cornerback Adoree' Jackson, so Houston should have plenty of opportunities to score.

The Texans certainly have their issues, but in this spot, I like them to pull off the upset.

Houston opened the season with a murderers' row schedule of opponents and this will be the weakest defense the Texans have faced the entire season. I’ll take the 3.5 points with Houston facing a divisional opponent on short rest and sprinkle a small percentage of my wager on the ML.

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Matthew Freedman: Vikings -4 vs. Falcons

Kickoff: 1 p.m. ET | More Game Info

With a 1-4 record, the Vikings are last in the NFC North and dangerously at risk of falling out of the NFC wildcard race altogether.

But this is a get-right spot for them.

Since head coach Mike Zimmer joined the team in 2014, the Vikings are 63-37-1 against the spread (ATS) in the regular season, good for an A-graded 22.2% return on investment (ROI).

And as you might expect with an ATS record that good, Zimmer has exhibited all sorts of regular-season edges throughout his tenure.

• At home: 30-16-1 ATS | 30.8% ROI
• As favorite: 36-20-1 | 24.9% ROI
• Outside of division: 45-18-1 | 38.2% ROI

These trends make sense within the context of who Zimmer is as a coach and what kind of team the Vikings have been under him.

Zimmer is a focused, no-nonsense, risk-adverse, process-oriented, defense-directed “manager” (for lack of a better word), and the Vikings have historically been a disciplined team that doesn’t often make big mistakes.

They don’t waste the natural advantage they have at home. They don’t play down to the level of their underdog opponents. They don’t present a known and easy challenge to teams that aren’t familiar with them.

This week, the Vikings are in a “solar eclipse” spot with all of Zimmer’s historical edges lining up.

As non-divisional home favorites, the Vikings are 19-4-1 ATS (59% ROI).

As for the 0-5 Falcons, they just fired head coach Dan Quinn.

Although he's no longer with the organization, this is still very much Quinn's team, and in his five-plus years with the Falcons, opponents were 48-37 ATS (9.9% ROI) — and 42-27 ATS (18.3% ROI) if we remove the Kyle Shanahan-spurred 2016 season.

For old time's sake, I'm treating this (unofficially) as the last game of the Quinn era — and that means I'm pretty much betting against the Falcons no matter what.

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Mike Randle: Eagles +9.5 vs. Ravens

Kickoff: 1 p.m. ET | More Game Info

Versatile running back Miles Sanders will attack the Ravens both on the ground and through the air. He has three games of 99 or more total yards and scored two touchdowns against the Steelers' league-leading rush defense last week. Now he faces a Ravens' run defense that has been stout as always, ranking third in Football Outsiders' DVOA, but has allowed the seventh-most receptions and eighth-most receiving yards to opposing running backs.

Sanders will find atypical production even against the Ravens' strong defensive front.

Philadelphia’s run defense has started to return to its normal elite level. Opposing running backs have tallied only 3.3 yards per carry against an Eagles' front four that's among the NFL’s best. Most importantly, cornerback Darius Slay is again playing a Pro Bowl level, and should limit production for diminutive Ravens wideout Marquise Brown.

This game features strength on strength with the Ravens rushing attack against the ground-stopping Eagles defense. With limited offensive weapons, Philadelphia head coach Doug Pederson knows he can’t survive a shootout, and Baltimore’s defense will not surrender a ton of points to an Eagles team limited at wide receiver.

The biggest concern is a mysterious knee injury to quarterback Lamar Jackson, which limited him to just three total rushing yards in Week 5. If Jackson’s mobility is again compromised, the Ravens lose a major part of their offensive attack.

The most reliable units in this game are both defenses, and the Ravens don't have the offensive firepower against Philadelphia's defensive line to win by double digits.

With Jackson’s health unknown, I'm backing the Eagles at +9.5 and would take them down to +9.

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Brandon Anderson: Jaguars +3 vs. Lions

Kickoff: 1 p.m. ET | More Game Info

Each Sunday night before I dig deep into the next week’s slate, I try to predict what the lines will be — it’s a good way to get an early feel for the game before the betting line dictates things. And when I looked at Lions-Jaguars, I did indeed have it at 3.5 … I just had the other team favored.

Wait, what?!

The Detroit Lions take one week off and suddenly we're making them a road favorite? Sure, a bye week gives Detroit a nice rest advantage, but what else about these Lions make them look like a road favorite against anyone, really?

Like every other Detroit team under Matt Patricia, these Lions are absolutely horrible on defense. They’re third to last in Football Outsiders’ defensive DVOA, about where they usually are under Patricia. Of course, the naysayer would point out that Jacksonville is one of the two defenses ranked even worse. Sure enough.

The problem is Detroit’s offense hasn’t been very good, either, while Jacksonville’s has. I trust Gardner Minshew more than Matt Stafford right now, especially with D.J. Chark on the field, and rookie RB James Robinson projects to have a huge game against this terrible Lions run defense.

Patricia was supposed to be a defensive guy, but do you really think he fixed something during the bye that he hadn’t already done the last few years? I’m going the other way. I think the Jaguars win a shootout outright and might grab the moneyline here if the line drops below +3. Maybe Jacksonville will hang so many points on Patricia that he’ll be the next head coach on the hot seat.