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Panthers vs. Cardinals Odds & Betting Predictions - September 14, 2025

Panthers at Cardinals

8:05 pm • CBS
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Carolina Panthers

5-12
@

Arizona Cardinals

8-9

Panthers at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Panthers
5-12
+4.5
+4.5-110
o46.5-110
+164
Cardinals
8-9
u46.5
-4.5-110
u46.5-110
-198
location pinSunday 8:05 p.m.
September 14, 2025
State Farm StadiumGlendale

Panthers vs. Cardinals Props

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Panthers vs. Cardinals Public Betting Percentages

Away Logo

Panthers

Public

Home Logo

Cardinals

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Cardinals are 4-1 in their last 5 games.
  • Cardinals are 5-0 in their last 5 games against the spread
  • Cardinals are 5-3 in their road games against the spread
  • The totals have gone OVER in 1 of Cardinals' last 5 games
  • The totals have gone OVER in 5 of Cardinals' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		11-66-35-33-47-2
Panthers		8-94-43-50-18-8

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		8-8-15-43-4-15-22-6-1
Panthers		13-47-16-21-012-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		8-9N/AN/A3-44-5
Panthers		5-12N/AN/A0-15-11

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 5thSFW 47-24-5.5 WO 43.5ARI -240
Dec 29th@LAL 9-13+6.5 WU 48LA +245
Dec 22nd@CARL 30-36-5.5 LO 47CAR -245
Dec 15thNEW 30-17-6 WO 46.5ARI -264
Dec 8thSEAL 18-30-3 LO 45.5SEA -177

Cardinals vs. Panthers Injury Updates

Cardinals Injuries

  • Calais Campbell
    DE

    Campbell is questionable with rest

    Questionable

  • Dalvin Tomlinson
    DT

    Tomlinson is questionable with knee

    Questionable

  • James Conner
    RB

    Conner is out with knee

    Out

  • Evan Brown
    OL

    Brown is questionable with neck

    Questionable

  • Sean Murphy-Bunting
    CB

    Murphy-Bunting is questionable with hand

    Questionable

  • Jalen Thompson
    S

    Thompson is questionable with ankle

    Questionable

  • Jonah Williams
    OL

    Williams is questionable with illness

    Questionable

  • Mack Wilson
    LB

    Wilson is questionable with ankle

    Questionable

  • Mykal Walker
    OLB

    Walker is questionable with illness

    Questionable

  • Blake Gillikin
    P

    Gillikin is out with foot

    Out

  • Baron Browning
    OLB

    Browning is questionable with neck

    Questionable

  • Simi Fehoko
    WR

    Fehoko is questionable with elbow

    Questionable

  • Joey Blount
    S

    Blount is out with ribs

    Out

  • Paris Johnson
    OL

    Johnson is out with knee

    Out

  • Michael Wilson
    WR

    Wilson is questionable with hamstring

    Questionable

  • Jammie Robinson
    S

    Robinson is doubtful with knee

    Doubtful

  • Dante Stills
    DE

    Stills is questionable with back

    Questionable

  • Emari Demercado
    RB

    Demercado is out with back

    Out

  • Trey Benson
    RB

    Benson is out with ankle

    Out

  • Elijah Jones
    DB

    Jones is out with ankle

    Out

  • Xavier Thomas
    DE

    Thomas is questionable with back

    Questionable

Panthers Injuries

  • A'Shawn Robinson
    DE

    Robinson is questionable with knee

    Questionable

  • Taylor Moton
    T

    Moton is questionable with knee

    Questionable

  • Josey Jewell
    LB

    Jewell is out with neck

    Out

  • Robert Hunt
    G

    Hunt is questionable with illness

    Questionable

  • Damien Lewis
    G

    Lewis is questionable with illness

    Questionable

  • Dominique Dafney
    TE

    Dafney is out with undisclosed

    Out

  • Jaycee Horn
    CB

    Horn is out with hip

    Out

  • Bobby Brown
    NT

    Brown is questionable with shoulder

    Questionable

  • Chuba Hubbard
    RB

    Hubbard is questionable with rest

    Questionable

  • Patrick Jones
    OLB

    Jones is out with knee

    Out

  • Amare Barno
    OLB

    Barno is out with shoulder

    Out

  • DJ Johnson
    OLB

    Johnson is out with rest

    Out

  • Trevin Wallace
    LB

    Wallace is out with shoulder

    Out

  • Chau Smith-Wade
    DB

    Smith-Wade is out with illness

    Out

See more NFL Injuries Right Arrow
Depth Charts
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Starter2ND3RD4TH
QBKyler MurrayClayton Tune
RBJames ConnerTrey BensonEmari DemercadoDeeJay Dallas
WRGreg DortchZay JonesAndre Baccellia
TETrey McBrideElijah HigginsTip ReimanTravis Vokolek
LTParis JohnsonKelvin BeachumChristian Jones
LGEvan BrownIsaiah Adams
CHjalte FroholdtTrystan Colon
RGWill HernandezJon Gaines
RTJonah WilliamsJackson Barton
LDEBilal NicholsDarius RobinsonBen Stille
RDEJustin JonesL.J. CollierDante Stills
WLBKyzir WhiteKrys Barnes
MLBMack WilsonOwen Pappoe
LCBSean Murphy-BuntingElijah Jones
SSBudda BakerDadrion Taylor-DemersonAndre ChachereDarren Hall
FSJalen ThompsonJoey Blount
RCBMax MeltonStarling Thomas
PBlake Gillikin
HBlake Gillikin
PRGreg DortchDeeJay DallasXavier WeaverEmari Demercado
KRGreg DortchDeeJay DallasXavier WeaverEmari Demercado
LSAaron Brewer
NBGarrett WilliamsKei'Trel ClarkJaden Davis
LWRMarvin HarrisonXavier Weaver
RWRMichael WilsonZach PascalTejhaun Palmer
NTRoy LopezKhyiris TongaNaquan Jones
KMatt Prater
ROLBZaven CollinsJesse Luketa
LOLBDennis GardeckVictor DimukejeXavier Thomas

Panthers vs. Cardinals Odds Comparison

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Panthers at Cardinals Team Totals

MatchupOverUnder
Panthers
5-12
N/A
N/A
Cardinals
8-9
N/A
N/A