The Memphis Tigers take on the UAB Blazers in Birmingham, AL, on Saturday, Oct. 18. Kickoff is set for 4 p.m. ET on ESPN2.
Memphis is favored by 21.5 points on the spread with a moneyline of -1700. UAB, meanwhile, enters as a +21.5 underdog and sits at +950 on the moneyline to pull off the upset. The over/under sits at 63.5 points.
Here���s my Memphis vs. UAB prediction and college football picks for Saturday, October 18.
Memphis vs UAB Prediction
- Memphis vs. UAB Pick: Memphis -21.5
My UAB vs. Memphis best bet is on the Tigers to cover the spread. Find the best line available on our live NCAAF odds page.
Memphis vs UAB Odds
| Memphis Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-21.5 -110 | 63.5 -110o / -110u | -1700 |
| UAB Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+21.5 -110 | 63.5 -110o / -110u | +950 |
- Memphis vs UAB Spread: Memphis -21.5, UAB +21.5
- Memphis vs UAB Over/Under: 63.5 Points
- Memphis vs UAB Moneyline: Memphis -1700, UAB +950
Memphis vs UAB College Football Betting Preview
Saturday's Memphis vs. UAB American Conference clash fits a historically profitable betting system from our Bet Labs database.
Named "The Right Favorite," this college football system is built on recognizing when the betting market underestimates a favorite.
When an opponent is coming off a loss by 7-23 points in the regular season, public perception often inflates its chances of rebounding, yet those weaknesses typically carry into the next game.
By focusing on contests where the total is at least 55, the system narrows in on games expected to have higher scoring, which makes it more difficult for struggling teams to keep pace.
Limiting the sample to the first 11 games ensures the analysis applies before postseason adjustments in motivation and preparation occur.
Finally, the filter targets situations where the line is set with the other side catching points, but not in extreme ranges, allowing favorites to deliver consistent covers.
Together, these conditions create a profile where the favorite is positioned as the stronger play despite public bias suggesting otherwise.
This system boasts an all-time record of 655-481-22, good for a winning percentage of 57.7% and an ROI of 11.6%. In 2025 alone, this system has cashed at a 63% clip with an ROI of 20%.
Memphis vs UAB Pick, Betting Analysis
UAB is coming off a 53-33 beatdown at the hands of a Florida Atlantic team that had only beaten Florida A&M and Rice to that point.
The Blazers finished the week by firing head coach Trent Dilfer in the midst of his third season.
Everything sets up well for Memphis here.
The Tigers rank third in the American Conference in scoring offense (40.5 points per game) and total offense (450.2 yards per game).
More importantly, UAB ranks dead last in the country in scoring defense, giving up 41.3 points per game — eight points below the second-worst American Conference team. That includes 42 to FCS Alabama State, 38 to Navy, 28 to Akron, 56 to Tennessee, 31 to Army and 53 to FAU.
With an offense that ranks top-40 in both Success Rate and Finishing Drives, the Tigers should be able to do whatever they want here.
Given the matchup on the field and the system at play, we'll lay the points with Memphis on Saturday afternoon.
Pick: Memphis -21.5
Memphis vs UAB Betting Trends
