The San Jose State Spartans take on the Wyoming Cowboys in Laramie, Wyoming. Kickoff is set for 7:00 p.m. EDT on CBS Sports Network.
San Jose State is favored by -1.5 points on the spread with a moneyline of -126. The total is set at 49.5 points.
Here’s my San Jose State vs. Wyoming prediction and college football picks for Saturday, October 11, 2025.
San Jose State vs Wyoming Prediction
- San Jose St vs. Wyoming Pick: Under 49.5 (-110, bet365)
My Wyoming vs. San Jose State best bet is on the Under. Find the best line available on our live NCAAF odds page.
San Jose State vs Wyoming Odds
| San Jose St Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2 -110 | 49.5 -110o / -110u | -125 |
| Wyoming Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2 -110 | 49.5 -110o / -110u | +105 |
- San Jose State vs Wyoming point spread: San Jose State -2 (-110), Wyoming +2 (-110)
- San Jose State vs Wyoming over/under: 49.5 (-110o / -110u)
- San Jose State vs Wyoming moneyline: San Jose State -125, Wyoming +105
San Jose State vs Wyoming Preview
This game activated one of our PRO betting systems, powered by Evan Abrams:
Early Unranked Unders is a college football system that identifies value in early-season matchups where neither team is ranked and expectations for offense are often overstated.
In the first 10 games of the season, unranked teams often lack the consistency and firepower of top programs, resulting in sloppy execution, conservative play-calling, and a slower tempo.
The system focuses on regular-season contests where the closing total is above 46, a range that signals scoring potential but often proves inflated when factoring in real game conditions.
Additional filters, such as wind speeds above six MPH and temperatures no higher than 66 degrees, further suppress offensive efficiency, creating an environment where scoring struggles to match market projections.
With the home spread allowed to range broadly from slight underdogs to heavy favorites, the system captures a wide spectrum of unranked contests where defenses or conditions keep outcomes tighter and lower-scoring than the total suggests, making the under a profitable angle.
Weird things happen in Laramie, and I am willing to bet against San Jose State’s decent pass attack (57th nationally in EPA per Dropback) at elevation with projected 12 MPH winds.
Furthermore, I’m willing to bank on Wyoming’s defense in general. The Cowboys rank 24th nationally in EPA per Play allowed, mostly because they’ve been excellent at preventing explosives while ranking third nationally in Defensive Finishing Drives.
The Cowboys aren’t nearly as good at stopping the run, but San Jose State can’t run the ball (99th nationally in EPA per Rush). Even if the Spartans find some consistency on the ground, a rush-heavy game script would still help my wager on the Under.
On the other side of the ball, I don’t trust Wyoming’s offense in general, as the Cowboys rank 97th nationally in EPA per Play.
While San Jose State’s defense is horrendous, I’m mainly banking on Wyoming’s defense showing up at home and shutting down the Spartans en route to a lower-scoring game.
Pick: Under 49.5 (-110, bet365)
