The Oklahoma Sooners take on the South Carolina Gamecocks in Columbia, South Carolina. Kickoff is set for 12:45 p.m. ET on SEC Network.
Oklahoma is favored by 5.5 points on the spread with a moneyline of -220. The total is set at 43 points.
Here’s my Oklahoma vs. South Carolina prediction and college football picks for Saturday, October 18.


Oklahoma vs South Carolina Prediction, Picks
- Oklahoma vs. South Carolina Pick: 1H Under 21 (-110, bet365)
My South Carolina vs. Oklahoma best bet is on the first-half Under. Find the best line available on our live NCAAF odds page.
Oklahoma vs South Carolina Odds, Spread, Line
Oklahoma Odds | ||
---|---|---|
Spread | Total | Moneyline |
-4 -112 | 42.5 -112o / -108u | -192 |
South Carolina Odds | ||
---|---|---|
Spread | Total | Moneyline |
+4 -108 | 42.5 -112o / -108u | +160 |
- Oklahoma vs South Carolina Spread: Oklahoma -4, South Carolina +4
- Oklahoma vs South Carolina Over/Under: 42.5
- Oklahoma vs South Carolina Moneyline: Oklahoma ML -192, South Carolina ML +160


Oklahoma vs South Carolina College Football Betting Preview
This is clearly a first-half Under.
I don’t trust what John Mateer is saying. I don’t think he’s healthy.
South Carolina can play a little defense, ranking 20th nationally in Stuff Rate. The Gamecocks should stop the underwhelming Oklahoma rush attack, which ranks 110th nationally in EPA per Rush, and an injured Mateer won’t be able to save the day on the road.
Meanwhile, I don’t trust that South Carolina’s offensive line — which may be down multiple starters — will get a push against Oklahoma’s elite defensive line that always travels.
LaNorris Sellers has 151 scramble yards this year because he’s always under pressure. He might not have a single clean pocket on Saturday.
I expect this game to be sluggish and slow from the jump and stay that way for 30 minutes.
Pick: 1H Under 21 (-110, bet365)