The Wisconsin Badgers take on the Notre Dame Fighting Irish in Green Bay, WI, on Sunday, Sept. 6. Kickoff is set for 7:30 p.m. ET on NBC and Peacock.
Notre Dame is favored by -21.5 points on the spread with a moneyline of -2000. Wisconsin, meanwhile, enters as a +21.5 underdog and is +1000 on the moneyline to pull off the upset. The over/under sits at 46.5 total points.
Here are my Wisconsin vs. Notre Dame prediction and college football picks for Sunday, September 6.
Wisconsin Badgers vs Notre Dame Fighting Irish Predictions, Pick
- Wisconsin vs. Notre Dame Pick: 1H Under 24 (-125) · CJ Carr 2+ TDs (+1400)
My Notre Dame vs. Wisconsin best bets are on the first-half under and CJ Carr to score two or more touchdowns. Find the best line available on our live NCAAF odds page.
Wisconsin vs Notre Dame Odds, Point Spread, Over/Under
| Wisconsin Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+21.5 -115 | 46.5 -110o / -110u | +1000 |
| Notre Dame Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-21.5 -105 | 46.5 -110o / -110u | -2000 |
- Wisconsin vs Notre Dame Spread: Wisconsin +21.5, Notre Dame -21.5
- Wisconsin vs Notre Dame Over/Under: 46.5 (-110o / -110u)
- Wisconsin vs Notre Dame Moneyline: Wisconsin ML +1000, Notre Dame ML -2000
Wisconsin vs Notre Dame Betting Preview
Wisconsin Badgers
Adding Colton Joseph from the transfer portal could be the factor that improves the Wisconsin offense. The Badgers finished 2025 near dead last in numerous offensive categories, including Finishing Drives, pass explosives and Havoc allowed.
Those numbers are uncharacteristic of coordinator Jeff Grimes, who previously had successful stops at BYU, Baylor and Kansas.
Joseph thrived in the Old Dominion offense last season, generating 34 all-purpose touchdowns to go along with over 1,000 rushing yards.
The junior logged a massive change in his statistical profile from 2024 to 2025, doubling his big-time throw rate and cutting his turnover-worthy play rate in half.
Grimes has had success with dual-threat quarterbacks, including Zach Wilson and Jalon Daniels. Joseph could be next in line.
Notre Dame Fighting Irish
Notre Dame will look to avenge a missed College Football Playoff appearance from last season.
Head coach Marcus Freeman will field one of the best defenses in the nation, returning seven of the top eight players in the secondary and five of the top six linebackers.
Freeman utilized the portal in an attempt to improve the defensive line, landing Tionne Gray from Oregon and Francis Brewu from Pitt on the inside.
On the other side of the ball, quarterback CJ Carr will begin his Heisman Trophy campaign with questions about the Irish's weapons at the skill positions.
Running backs Jeremiyah Love and Jadarian Price have both moved on to the NFL, leaving experience as the biggest question mark in the backfield.
Carr returns top target Jordan Faison, as well as slot receiver Jaden Greathouse after an injury-plagued 2025.
Wisconsin vs Notre Dame Week 1 Pick to Make
Notre Dame will look to establish the run with a bevy of inexperienced running backs. Aneyas Williams leads the unit on the depth chart but has racked up only 59 carries in two seasons.
Expectations are high for Nolan James Jr., who appeared in four games last year. I could take the Irish a number of possessions to create a quality drive against a Wisconsin defense that has one of the best linebacker units in the Big Ten.
Mason Posa and Cooper Catalano combined for 82 tackles last season, while edge Sebastian Cheeks recorded 27 pressures.
No explosives are expected from Joseph against the Irish defense, particularly with new faces at nearly every position on the offensive line two-deep.
On the other side, Notre Dame's explosives will come from Carr's arm, as the Wisconsin secondary will carry as many questions as last season. The Badgers finished 2025 outside the top 100 in coverage grading and Pass EPA allowed.
Look for a lower-scoring game with a few pass explosives coming from the Notre Dame offense.
Pick: 1H Under 24 (-125) · CJ Carr 2+ TDs (+1400)
Wisconsin vs Notre Dame Trends to Watch
