The Rice Owls take on the UTSA Roadrunners in San Antonio, Texas. Kickoff is set for 7:30 p.m. ET on ESPNU.
UTSA is favored by 12.5 points on the spread with a moneyline of -500. The total is set at 49 points.
Here’s my Rice vs. UTSA prediction and college football picks for Saturday, October 11, 2025.
Rice vs UTSA Prediction
- Rice vs. UTSA Pick: UTSA -12.5 (-110, bet365)
My UTSA vs. Rice best bet is on the Roadrunners to cover. Find the best line available on our live NCAAF odds page.
Rice vs UTSA Odds
| Rice Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+12.5 -115 | 49 -110o / -110u | +375 |
| UTSA Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-12.5 -105 | 49 -110o / -110u | -500 |
- Rice vs UTSA point spread: UTSA -12.5
- Rice vs UTSA over/under: 49 points
- Rice vs UTSA moneyline: Rice +375, UTSA -500
Rice vs UTSA Preview
UTSA’s offense has sputtered over the past few weeks, as the Roadrunners have pieced together back-to-back offensive stinkers against Colorado State and Temple.
If they want to get back into the American race, they need this win. They have North Texas, Tulane and South Florida over the next three weeks.
I think Owen McCown and UTSA’s offense get off the mat against a Rice defense that ranks 130th in Explosiveness allowed and 97th in Havoc created. The Owls have generated two sacks over the past two weeks.
The Roadrunners should shred this defense behind an offensive line that’s helped generate the nation’s highest Rush Explosiveness rate and 17th-highest EPA per Rush.
Rice allows plenty of Rush Explosives, and the Owls’ defensive line is beginning to wear down after facing 87 rush attempts over the past two weeks.
On the other side of the ball, Rice doesn’t have much punch on offense. The Owls rank last nationally in Explosiveness and 133rd in EPA per Play.
The Roadrunners are desperate and have enough ammo on offense to take advantage of a vulnerable Rice defense in a big victory.
Pick: UTSA -12.5 (-110, bet365)
